疏风化痰方对咳嗽变异性哮喘外周血白三烯C4、EOS及IgE的影响  

Clinical Observation on the Effects of Shufeng Huatan Decoction on Leukotriene C4 of Peripheral Blood,EOS and Ig E in Cough Variant Asthma

作　　者：胡伟林[1] 赵珊珊[1] 涂明利[1] 周耀政[1] 

机构地区：[1]湖北医药学院附属随州医院,湖北随州441300

出　　处：《中国中医急症》2016年第5期889-892,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖北省教育厅科研项目(B20122408);湖北省自然科学基金(2013CFB468)

摘　　要：目的观察疏风化痰方对变异性哮喘患者外周血白三烯C4(LTC4)、嗜酸性粒细胞(EOS)及免疫球蛋白E(Ig E)的影响。方法 70例患者按随机数字表法分为治疗组和对照组各35例。治疗组给予疏风化痰方、孟鲁司特钠片治疗,对照组给予孟鲁司特钠片治疗,两组均治疗12周,随访24周。观察两组治疗前后症状体征,检测治疗前后及随访外周血LTC4、EOS及Ig E,分析两组患者未复发率,观察记录两组患者的不良反应。结果治疗组35例,治疗过程中脱落1例(失联1例),余34例;对照组35例,治疗过程中脱落2例(未按本方案规定用药1例、个人原因退出试验1例),余33例。治疗组总有效率91.18%优于对照组的78.79%(P<0.05)。两组治疗后LTC4与治疗前比较均下降(P<0.01),两组间比较差别不大(P>0.05)。随访治疗组、对照组LTC4较治疗前仍下降明显(P<0.01或P<0.05),且治疗组优于对照组(P<0.05)。两组治疗后Ig E均较治疗前下降(P<0.01),且治疗组优于对照组(P<0.05)。随访治疗组、对照组Ig E较治疗前明显下降(P<0.01或P<0.05),且治疗组优于对照组(P<0.01)。两组治疗后EOS均较治疗前下降(P<0.01或P<0.05),且治疗组优于对照组(P<0.05)。随访治疗组EOS较治疗前仍下降(P<0.05),对照组EOS较治疗前差别不大(P>0.05),治疗组优于对照组(P<0.05)。治疗组有效31例,截止随访结束,未复发26例,未复发率83.87%。对照组有效26例,截止随访结束,未复发15例,未复发率57.69%。治疗组复发情况明显低于对照组(P<0.05)。两组治疗前后的血、尿、粪常规,肝、肾功能检测,心电检查均未见明显异常。治疗组3例、对照组6例出现一过性胃肠道反应(腹痛、腹泻),未影响观察效果。结论治疗组临床疗效明显优于对照组,可降低外周血LTC4、EOS及Ig E,显著减少复发,预后良好稳定。Objective： To observe the effects of Shufeng Huatan Decoction on leukotriene C4 of peripheral blood,EOS and Ig E in cough variant asthma. Methods： 70 cases were randomly divided into the treatment group and the control group,35 cases in each. The treatment group took Shufeng Huatan Decoction and montelukast sodium tablets,while the control group only took montelukast sodium tablets. The treatment course lasted for 12 weeks with 24 weeks of follow-up. Before and after treatment,in both groups,symptoms and signs were observed;leukotriene C4 of peripheral blood,EOS and Ig E were detected;non-recurrence rate was analysed and adverse reaction was recorded. Results： Among 35 cases,there was 1 case losing touch and 34 cases remaining in the treatment group,while 2 cases losing touch and 33 cases remaining in the control group. The total efficiency of the treatment group was 91.18%,better than the control group 78.79%（P 0.05）. Compared with before treatment,LTC4 decreased in both groups after treatment（P 0.01）. There was little difference between the two groups（P 0.05）. In follow-up of both groups,LTC4 decreased obviously,and the difference was statistically significant（P 0.05 or P 0.01）,and the treatment group was better than the control group（P 0.05）. Compared with before treatment,Ig E decreased in both groups after treatment（P 0.01） and the treatment group was better than the control group（P 0.05）. In follow-up,Ig E in the treatment group decreased obviously after treatment（P 0.01 or P 0.05）,and the treatment group was better than the control group（P 0.01）. After treatment,EOS decreased in both groups（P 0.05 or P 0.01）,and the treatment group was better than the control group（P 0.05）. In followup,Ig E in the treatment group decreased after treatment（P 0.05）,while there was little difference in the control group before and after treatment（P 0.05）,and the treatment group was better than the control group（P 0.05）.There were 31 effective cases in the treatment

关 键 词：咳嗽变异性哮喘 疏风化痰方 孟鲁司特钠 

分 类 号：R562.25[医药卫生—呼吸系统]