地佐辛预防老年患者苏醒期躁动的效果观察  

Effects of Dezocineon Prevention of Restlessness during Recovery in Elderly Patients

作　　者：洪黎霞[1] 张骐[1] 王玉龙[1] 

机构地区：[1]安徽省芜湖市第二人民医院麻醉恢复室,安徽芜湖241000

出　　处：《中国伤残医学》2016年第9期5-7,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：观察地佐辛预防老年患者苏醒期躁动的效果。方法：选择56例ASAI～Ⅱ级择期老年手术患者，随机分成观察组和对照组，每组各28例，观察组在手术结束前15分钟静脉注射地佐辛0．1mg／kg，对照组不做任何处理。记录2组患者术毕苏醒时间、拔管时间、麻醉恢复室（post—anesthesia care unit，PACU）驻留时间，苏醒期发生躁动的例数和躁动评分及术后恶心、呕吐、嗜睡、呼吸抑制等不良反应事件的发生情况。结果：2组患者苏醒时间、拔管时间差异无统计学意义（P〉0．05），观察组PACU驻留时间比对照组明显缩短，差异有统计学意义（P〈0．05）；对照组躁动的发生率（57．14％）明显大于观察组（7．14％），且严重躁动（2～3级）的比例也明显高于实验组。观察组患者恶心、呕吐的发生率比对照组明显降低，差异有统计学意义（P〈0．05）；2组患者嗜睡、呼吸抑制等不良反应事件的比较差异无统计学意义（P〉0．05）。结论：地佐辛可安全有效地预防老年患者苏醒期躁动的发生，不影响复苏速度，且不良反应少，提高患者的苏醒质量。Objective： To observe the effects of dezocine on prevention of restlessness during recovery in elderly patients. Methods： 56 cases of elderly surgical patients at grade I - II according to the ASA classification were randomized into the observation group and the control group, 28 cases in each group. The observation group was given intravenous injection of dezocine （0.1 mg/kg） since 15min before the end of the operation while the control group was untreated. The two groups of patients were recorded for the postoperative awaking time, extubation time, PACU （post - anesthesia care unit） time, and the number of cases of restlessness during recovery period and PAED scores, and adverse events such as postoperative nausea, vomiting, drowsiness, respiratory depression. Results： There were no statistical significances between two groups of patients in awaking time and extubation time （ P 〉 0.05 ）. PACU time was significantly shor- ter in the observation group than that of the control group （ P 〈 0.05 ） ; the incidence of restlessness was obviously larger in the control group （57.14%） than in the observation group （7.14%）, and the proportion of serious restlessness （ grade II -III） was also larger than the experimental group. The incidences of nausea and vomiting in the observation group were significantly lower than the control group （ P 〈 0.05 ） ; and there were no statistically significant differences between the two groups of patients in adverse events such as drowsiness and respiratory depression （ P 〉 0.05 ）. Conclusions ： Dezocine can safely and effectively prevent the incidence of restlessness during recovery in elderly patients. It does not affect the speed of recovery and has less adverse reactions so as to improve the quality of awakening.

关 键 词：地佐辛 老年患者 苏醒期躁动 

分 类 号：R614[医药卫生—麻醉学]