3DT_1 WI用于海马多体素波谱扫描定位的初步研究  

Study of using three-dimensional T_1 weighted imaging for hippocampus magnetic resonance spectroscopy localization

作　　者：刘任远[1] 廖文清[2] 武文博[3] 周飞[3] 李茗[4] 张鑫[4] 俞海平[4] 朱斌[4] 张冰[4] 徐运[1] 

机构地区：[1]南京大学医学院附属鼓楼医院神经内科,江苏南京210008 [2]东南大学生物科学与医学工程学院生物电子学实验室,江苏南京210009 [3]南京医科大学附属鼓楼临床医学院,神经内科江苏南京210008 [4]南京大学医学院附属鼓楼医院医学影像科,江苏南京210008

出　　处：《东南大学学报（医学版）》2016年第2期232-235,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨使用二维T_2加权成像(2DT_2W)和三维T_1加权成像(3DT_1W)定位对海马多体素磁共振波谱成像(magnetic resonance spectroscopy,MRS)准确性的影响。方法:使用荷兰Philips公司Achieva 3.0 T TX磁共振成像系统,对7名健康志愿者分别采用2DT_2W和3DT_1W进行海马MRS定位,对比两种定位方法MRS测定的感兴趣区覆盖的海马体积差异,MRS测得的代谢物N-乙酰天门冬氨酸(N-acetylaspartate,NAA)、肌醇(myo-inositol,m I)与内参肌酸(creatine,Cr)的相对浓度(NAA/Cr与m I/Cr)差异以及NAA、m I的信噪比差异。结果:与2DT_2W定位比较,3DT_1W定位MRS感兴趣区覆盖的海马体积增加,NAA信噪比降低,NAA/Cr升高,但差异均无统计学意义(P>0.05);m I信噪比降低,差异有统计学意义(P=0.028)。结论:使用3DT_1W定位MRS有助于提升定位准确性,但可能伴随海马代谢物信噪比降低。更好的定位及更全面的评价方法仍有待进一步研究。Objective：To compare effect of localizing magnetic resonance spectroscopy （ MRS） for hippocampus by using of axial two demensional T2 weighted （2DT2W） imaging and whole brain three dimensional T1 weighted （3DT1 W） imaging.Methods：MRI examinations were performed at a 3 tesla scanner （ Achieva 3.0T TX,Philips Medical Systems , the Netherlands ） .Seven healthy participants were enrolled in this study .Hippocampal volume covered by the view of interest （ VOI ） , metabolite relative concentration measured by N-acetylaspartate （ NAA ） to creatine（Cr）ratio（NAA/Cr）and myo-inositol（mI）to Cr ratio（mI/Cr）and signal-to-noise ratio of the NAA and mI were compared.Results：The 3DT1 W approach covered a larger amount of mean hippocampal volume and with a higher NAA/Cr than that of the 2DT2 W approach.Signal-to-noise ratio of NAA detected by the 3DT1 W approach was lower than that detected by the 2DT2W approach.However,no statistical significance was observed （P〉0.05）. A lower signal-to-noise ratio of mI was detected by the 3DT1W approach in right hippocampus （P =0.028）. Conclusion：The 3 DT1 W approach might improve the accuracy of localization of hippocampal magnetic resonance spectroscopy .However ,reduced signal-to-noise ratio of the metabolites were observed .further researches are needed for a thorough evaluation .

关 键 词：多体素氢质子波谱 海马波谱成像 扫描定位技术 

分 类 号：R331[医药卫生—人体生理学]