基于实时功能磁共振神经反馈系统对初级运动皮层自主调节研究  

Autonomic Regulation of Primary Motor Cortex Using Real-time Functional Magnetic Resonance Imaging Neural Feedback Training

作　　者：娄江华[1] 马丽佳[1] 李中林[2] 闫镔[2] 史大鹏[1] 李永丽[1] 

机构地区：[1]郑州大学人民医院放射科,河南郑州450003 [2]解放军信息工程大学,河南郑州450002

出　　处：《中国医学影像学杂志》2016年第4期241-244,共4页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金面上项目(81271534);国家高技术研究发展计划(863计划)(2012 AA011603);河南省科技厅科技攻关项目(2012-2014)(132102310063);2012度河南省卫生厅科技攻关项目(201202023)

摘　　要：目的探讨实时功能磁共振神经反馈系统(rtfMRI)对正常志愿者初级运动皮层区(M1区)自主调节的作用。资料与方法基于课题组建立的rtfMRI,选取右侧M1区作为感兴趣区(ROI),把该ROI的磁共振血氧水平依赖成像(BOLD)信号以曲线的方式反馈给受检者,引导12例正常右利手志愿者通过运动想象进行M1区调节。在线数据采用TBV软件进行分析,观察ROI的BOLD信号改变,并进行组分析和3次训练前后比较右侧M1区信号变化程度。结果组分析显示,12例正常志愿者通过运动想象M1区上调差异有统计学意义(P<0.05);经过3次训练M1区的上调程度不断提高,差异有统计学意义(P<0.05)。结论应用rtf MRI在一定程度上能够帮助受检者自主调节初级运动皮层的活动。Purpose To explore the feasibility of real-time function magnetic resonance imaging（fMRI） on autonomic regulation of primary motor cortex area（M1） activation in normal volunteers. Materials and Methods Twelve right-handed healthy subjects were trained for three times to regulate the blood oxygenation level dependent（BOLD） response at the right M1 area（ROI） using real-time fMRI system. The BOLD signal intensity of the ROI was feedback to the subject in a curvilinear manner. Turbo-brain voyager（TBV） was used for online data analysis. The signal change of the right M1 area before and after training was compared. Results The BOLD signal intensity of all the subjects increased significantly at the M1 area over sessions（P〈0.05）. The signal intensity at M1 area for all of the subjects elevated constantly after trained for three times, which showed statistic difference（P〈0.05）. Conclusion Real-time feedback training is helpful to acquire autonomic regulation of primary motor cortex activation.

关 键 词：磁共振成像 血氧水平依赖成像 运动皮质 神经反馈 

分 类 号：R445.2[医药卫生—影像医学与核医学]