孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效及其对炎性因子、肺功能、免疫功能的影响研究  

Clinical Effect of Montelukast Sodium Combined With Seretide on Bronchial Asthma and the Impact on Inflammatory Cytokines,Pulmonary Function and Immunological Function

作　　者：姜增凯[1] 贾萍[1] 叶晓歌[1] 

机构地区：[1]河南省南阳市第二人民医院药学部,473000

出　　处：《实用心脑肺血管病杂志》2016年第4期49-52,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的分析孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效,探讨其对炎性因子、肺功能、免疫功能的影响。方法选取2014年2月—2015年2月南阳市第二人民医院收治的支气管哮喘患者112例,随机分为治疗组和对照组,各56例。对照组患者在常规治疗基础上给予沙美特罗替卡松粉吸入剂吸入治疗,治疗组患者在对照组基础上联合孟鲁司特钠治疗,两组患者疗程均为12周。比较两组患者临床疗效及治疗前后血清炎性因子水平〔白介素6(IL-6)和肿瘤坏死因子α(TNF-α)〕、肺功能指标〔呼气峰流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)〕、免疫功能指标(CD_3^+细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+比值),并观察治疗期间药物不良反应发生情况。结果治疗组患者临床疗效优于对照组(u=2.007,P=0.045)。治疗前两组患者血清IL-6和TNF-α水平比较,差异无统计学意义(P>0.05);治疗后治疗组患者血清IL-6和TNF-α水平低于对照组(P<0.05)。治疗前两组患者PEF、FVC、FEV1比较,差异无统计学意义(P>0.05);治疗后治疗组患者PEF、FVC、FEV1高于对照组(P<0.05)。治疗前两组患者CD_3^+细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+比值比较,差异无统计学意义(P>0.05);治疗后治疗组患者CD_3^+细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+比值均高于对照组(P<0.05)。治疗期间两组患者均未发生严重药物不良反应。结论孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效确切,能有效降低血清炎性因子水平,改善患者肺功能及免疫功能,且安全性较高。Objective To analyze the clinical effect of montelukast sodium combined with seretide on bronchial asthma,to investigate the impact on inflammatory cytokines,pulmonary function and immunological function. Methods A total of 112 patients with bronchial asthma were selected in the Second People＇ s Hospital of Nanyang from February 2014 to February2015,and they were randomly divided into control group and treatment group, each of 56 cases. Based on conventional treatment,patients of control group received extra seretide, while patients of treatment group received montelukast sodium combined with seretide,both groups treated for 12 weeks. Clinical effect,serum levels of inflammatory cytokines（ including IL-6 and TNF-α）,pulmonary function index（ including PEF,FVC and FEV1）,immunological function index（ including CD_3-＋cell percentage,CD_4-＋cell percentage and CD_4-＋/ CD_8-＋cell ratio） before and after treatment were compared between the two groups,and incidence of adverse reactions was recorded. Results The clinical effect of treatment group was statistically significantly better than that of control group（ u = 2. 007,P = 0. 045）. No statistically significant differences of serum level of IL-6 or INF- α was found between the two groups before treatment（ P〈0. 05）, while serum levels of IL-6 and TNF-α of treatment group were statistically significantly lower than those of control group after treatment（ P〈0. 05）. No statistically significant differences of PEF,FVC or FEV1 was found between the two groups before treatment（ P〈0. 05）,while PEF,FVC and FEV1 of treatment group were statistically significantly higher than those of control group after treatment（ P〈0. 05）. No statistically significant differences of CD_3-＋cell percentage,CD_4-＋cell percentage or CD_4-＋/ CD_8-＋cell ratio was found between the two groups before treatment（ P〈0. 05）,while CD_3-＋cell percentage,CD_4-＋cell percentage and CD_4-＋/ CD_8-＋cell ratio of treatment group were statisti

关 键 词：哮喘 孟鲁司特钠 沙美特罗替卡松粉 治疗结果 肺功能 免疫功能 

分 类 号：R562.25[医药卫生—呼吸系统]