阿托伐他汀对冠心病患者血脂及内皮脂酶的影响  

Impact of Atorvastatin on Blood Lipids and Endothelial Lipase of Patients With Coronary Heart Disease

作　　者：冯小智[1] 

机构地区：[1]延安大学附属医院心内科,陕西省延安市716000

出　　处：《实用心脑肺血管病杂志》2016年第4期105-107,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨阿托伐他汀对冠心病患者血脂及内皮脂酶的影响。方法选取延安大学附属医院2013年8月—2014年9月收治的冠心病患者120例,按照随机原则分为对照组与观察组,每组60例。两组患者入院后均给予生活方式调整及常规药物治疗,观察组患者在此基础上给予阿托伐他汀。比较两患者治疗前后血脂指标〔包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)〕、炎性因子〔一氧化氮(NO)及超敏C反应蛋白(hs-CRP)〕及内皮脂酶。结果两组患者治疗前TC、TG、LDL-C及HDL-C比较,差异均无统计学意义(P>0.05);观察组患者治疗后TC、TG、LDL-C低于对照组,HDL-C高于对照组(P<0.05)。两组患者治疗前NO、hs-CRP及内皮脂酶比较,差异均无统计学意义(P>0.05);观察组患者治疗后NO高于对照组,hs-CRP及内皮脂酶低于对照组(P<0.05)。结论阿托伐他汀可有效改善冠心病患者血脂代谢,降低内皮脂酶水平,升高HDL-C水平。Objective To investigate the impact of atorvastatin on blood lipids and endothelial lipase of patients with coronary heart disease（ CHD）. Methods A total of 120 patients with CHD were selected in the Affiliated Hospital of Yan＇an University from August 2013 to September 2014,and they were divided into control group and observation group according to randomized principle,each of 60 cases. Patients of both groups received lifestyle adjustment and conventional medical treatment after admission,while patients of observation group received extra atorvastatin. Blood liquids index（ including TC,TG,LDL-C and HDL-C）,inflammatory cytokines（ including NO and hs-CRP） and endothelial lipase were compared between the two groups before and after treatment. Results No statistically significant differences of TC,TG,LDL-C or HDL-C was found between the two groups before treatment（ P〈0. 05）; after treatment, TC, TG and LDL-C of observation group were statistically significantly lower than those of control group,while HDL-C of observation group was statistically significantly higher than that of control group（ P〈0. 05）. No statistically significant differences of NO,hs-CRP or endothelial lipase was found between the two groups before treatment（ P〈0. 05）; after treatment,NO of observation group was statistically significantly higher than that of control group,while hs-CRP and endothelial lipase of observation group were statistically significantly lower than those of control group（ P〈0. 05）. Conclusion Atorvastatin can effectively adjust the blood lipid metabolism,reduce the endothelial lipase and improve the HDL-C of patients with CHD.

关 键 词：冠心病 阿托伐他汀 降血脂药物 酯酶类 

分 类 号：R541.4[医药卫生—心血管疾病]