中国原发性皮肤毛霉病32例回顾性分析  

Retrospective analysis of primary cutaneous mucormycosis in China:a review of 32 cases

作　　者：吕红莉 李澄 李燕 谭娟 许人超 汤劲辉 

机构地区：[1]上海市嘉定区中心医院,上海201800

出　　处：《中国真菌学杂志》2016年第2期103-107,共5页Chinese Journal of Mycology

摘　　要：目的总结我国报道的原发性皮肤毛霉病的临床资料,探讨其流行病学特点、易感因素、临床表现、致病菌种及治疗策略。方法检索文献并回顾分析我国32例皮肤毛霉病的临床资料。结果共检索全文27篇,病例32例。患者的平均发病年龄为39.97岁,男女比例为9∶7,临床多表现为红斑、丘疹、结节,可缓慢扩展形成浸润性斑块伴溃疡坏死。诊断主要依赖于真菌学及组织病理学检查。治疗方法首选两性霉素B。结论原发性皮肤毛霉病是一种严重的毁容性深部真菌病,提高对本病的认识,有利于及早诊断和治疗,治疗首选两性霉素B。Objective To investigate and discuss the epidemiology,risk factors,clinical manifestations,pathomycete and treatment strategies for primary cutaneous mucormycosis.Methods Thirty-two cases of primary cutaneous mucormycosis were searched from the electrical database,and all the clinical information was collected and evaluated.Results Twenty-seven articles（32cases）were included in the study.Median age was 39.97 years old,with a male predominance（M∶F=9∶7）.The major clinical manifestations were local erythema,papula and nodule,which might spread into infiltrating plaque associated with ulceration and necrosis.Diagnosis was mainly dependent on mycologic and/or histopathological examination.Amphotericin B was the first-line antifungal drug for the disease.Conclusion Primary cutaneous mucormycosis is a rare severe devastatind deep fungal infection.Enhancing the understanding of its clinical characterisctics would contribute to the early diagnosis and timely treatment,and amphotericin B was the first-line choice.

关 键 词：毛霉病 皮肤毛霉病 接合菌病 

分 类 号：R519.8[医药卫生—内科学]