非孟德尔遗传模式:表观遗传学及其应用研究进展  

Non-Mendelian Inheritance Patterns: Advances in Epigenetics and Its Application

作　　者：王杰[1] 徐友信[2] 刁其玉[1] 张乃锋[1] 

机构地区：[1]中国农业科学院饲料研究所农业部饲料生物技术重点开放实验室,北京100081 [2]潍坊科技学院,山东寿光262700

出　　处：《中国农学通报》2016年第14期37-43,共7页Chinese Agricultural Science Bulletin

基　　金：公益性行业(农业)科研专项"南方地区幼龄草食畜禽饲养技术研究"(201303143)

摘　　要：为了阐明表观遗传学在人类疾病发生发展过程中的应用,首先阐释表观遗传学主要研究内容。然后对肿瘤、阿尔兹海默病、动脉粥样硬化及糖尿病等疾病过程中DNA甲基化、组蛋白修饰、染色质重塑以及非编码RNA等表观遗传修饰的分子机制进行了总结概括。该研究对进一步理解相关疾病的发病机理及其分子调控机制有重要意义。To clarify the application of epigenetics in the process of human disease development, researchcontent of epigenetics was reviewed. Then the molecular regulation mechanism of DNA methylation, histonemodification, chromatin remodeling and non-coding RNA in the process of related diseases including cancer,alzheimer＇s disease, atherosclerosis, and diabetes and other human diseases were reviewed. The results willhelp to further understand the pathogenesis of related diseases and its molecular regulation mechanism.

关 键 词：孟德尔遗传 表观遗传学 DNA甲基化 组蛋白修饰 染色质重塑 非编码RNA 

分 类 号：Q78[生物学—分子生物学]