大肠癌组织癌细胞中P-选择素的表达及其临床病理意义  

Expression and clinical significance of P-selectin in colorectal cancer cells

作　　者：罗春英[1] 黄炳臣[1] 黄琴[2] 陈家兴[2] 陆海善[1] 韦叶生[3] 王俊利[3] 黄照权[1] 

机构地区：[1]右江民族医学院附属医院病理科,广西百色533000 [2]右江民族医学院 [3]右江民族医学院附属医院检验科

出　　处：《天津医药》2016年第5期540-542,共3页Tianjin Medical Journal

基　　金：广西自然科学基金项目(2011GXNSFA018194);广西医学科学实验中心开放基金专项项目(KFJJ2011-05);自治区级大学生创新创业训练计划立项项目(201410599017)

摘　　要：目的：探讨P-选择素蛋白在大肠癌组织癌细胞中的表达及其临床病理意义。方法运用免疫组织化学法，采用P-选择素抗体检测116例大肠癌组织和57例癌旁正常组织P-选择素的表达情况，比较和分析P-选择素在大肠癌组织癌细胞和正常肠黏膜组织中的表达差异及其临床病理意义。结果 P-选择素在大肠癌组织中的癌细胞、血管内皮细胞均有表达。肿瘤细胞P-选择素阳性表达率（77.6%，90/116）明显高于癌旁正常肠黏膜组织中腺上皮细胞P-选择素的阳性表达率（17.5%，10/57），差异有统计学意义（χ^2=56.49，P＜0.05）。然而，肿瘤细胞P-选择素阳性表达率在不同肿瘤直径、分化程度、浸润深度和有无淋巴结转移患者间比较差异无统计学意义（80.6%vs.74.1%、79.0%vs.74.3%、78.4%vs.76.9%、82.7%vs.73.4%，均P＞0.05）。结论大肠癌肿瘤组织中癌细胞表达P-选择素是该肿瘤的重要特征。Objective To investigate the expression and clinical significance of P-selectin in colorectal cancer cells. Methods The protein expression of P-selectin was detected by immunohistochemistry in colorectal cancer tissues （ n=116） and corresponding non-tumor normal mucosa（n=57）. The differences of P-selectin expression in colorectal cancer tissues, corre？sponding non-tumor normal mucosa and the clinical pathological significance were compared and analysed in two groups. Results The expression of P-selectin protein was found not only in vascular endothelial cells but also in colorectal cancer cells. The positive rate of P-selectin expression was apparently higher in colorectal cancer cells （77.6%, 90/116） than that in normal mucosa （17.5%, 10/57,χ^2=56.49, P〈0.05）. However, there were no significance in positive rates of P-selectin in colorectal cancer cells between tumors with different diameters, different degrees of differentiation, different depths of infiltration and with or without lymph node metastasis （80.6%vs. 74.1%, 79.0%vs. 74.3%, 78.4%vs. 76.9%, 82.7%vs. 73.4%, P〉0.05）. Conclusion The high expression of P-seletin in colorectal cancer cells is an important characteristic of colorectal cancer.

关 键 词：结直肠肿瘤 P选择素 免疫组织化学 大肠癌 

分 类 号：R541.4[医药卫生—心血管疾病]