有机磷农药中毒患者预后的危险因素分析  

Analysis on influencing factors of prognosis of patients with acute organophosphorus pesticide poisoning

作　　者：郭聪芳[1] 王峪[1] 刘剑虹[1] 沈鹏[1] 王颢[1] 魏永军[1] 史晓峰[1] 周兴举[1] 王巍巍[1] 

机构地区：[1]天津市第一中心医院,300192

出　　处：《中华劳动卫生职业病杂志》2016年第5期372-374,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的对影响急性有机磷农药中毒患者预后的危险因素进行分析。方法选取2010年1月至2015年1月就诊于我院的有机磷农药中毒患者67例，分析患者的APACHE Ⅱ评分，血D-二聚体（DD2），C反应蛋白（CRP），降钙素原（PCT），乳酸等指标及临床资料，根据患者治疗效果将患者分为存活组53例和死产组14例，用Logistic同归分析筛选能独立预测患者预后的相关因素。结果死亡组患者APACHE Ⅱ，DD2、CRP、PCT明艟高于存活组，差异有统计学意义（P〈0．05），其中APACHE Ⅱ，CRP是影响患者预后的独立危险因素（P〈0．05）。APACHE评分26分为评估急性有机磷农药中毒患者预后的最佳临界值。结论APACHE Ⅱ评分与CRP在对患者的预后的评估中发挥重要作用，其中APACHE Ⅱ〉26分提示患者预后较差。Objective To analyze the relationship between risk factors and prognosis of acute organophosphorus pesticide poisoning （AOPP）. Methods The clinical data including APACHE Ⅱ, D-dimer, C- reactive protein, procalcitonin, lactic acid of the 67 eases of acute organophosphorus pesticide poisoning which respectively divided into survival group and death group by the outcome were collected . The independent influcing factors were got by logistic regression analysis. Results The analysis showed that APACHE Ⅱ ,D- dimer,C-reaetive protein and Proealeitonin were influencing factors to evaluate prognosis of AOPP （P〈0.05）. Meanwhile, APACHE Ⅱ and CRP were the independent influencing factors to evaluate prognosis of AOPP（P〈 0.05）.APACHE Ⅱ 26 分 was the optimum thresholds to acess the prognosis of AOPP and its Youden index was largest. Conclusion APACHE Ⅱ and CRP played an important role in the assessment of prognosis on AOPP. When APACHE Ⅱ was more than 26, it suggested the patient of AOPP will have a bad prognosis.

关 键 词：杀虫药 有机磷 中毒 C-反应蛋白 

分 类 号：R595.4[医药卫生—内科学]