地氯雷他定的抗炎机制研究进展  

Advance of anti-inflammatory properties of desloratadine

作　　者：陈美灵[1] 周珮珮 许淑红[1] 崔亚娇 吴玉林[1] 

机构地区：[1]中国药科大学基础医学与临床药学学院,江苏南京211198

出　　处：《中国临床药理学与治疗学》2016年第3期335-340,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家“重大新药创新”科技重大专项(2013ZX09301303001007)

摘　　要：过敏性鼻炎是Ig E介导的鼻黏膜组织的一种非感染性炎症,炎症细胞的浸润和炎症介质的释放,加剧了过敏性鼻炎患者的临床症状。本文综述了参与过敏反应的关键介质和地氯雷他定抗炎特性的最新研究进展,为抗组胺药物的临床治疗提供一定的指导意义。Allergic rhinitis is an IgE-mediated nasal mucosa noninfectious inflammation and is asso- ciated with robust infiltration of immune cells and mediators which may contribute to clinical manifesta- tions of the allergic disease. Key mediators involved in the allergic response and pathophysiological and clinical manifestations of the immune response are reviewed in this article. Desloratadine was used as a probe in order to further elucidate the anti-inflamma- tory mechanisms involved during an allergic response and help to provide some guidance for the clinical treatment of antihistamines.

关 键 词：过敏性鼻炎 地氯雷他定 病理生理学 抗炎特性 

分 类 号：R765[医药卫生—耳鼻咽喉科]