桂枝茯苓胶囊对原发性痛经患者炎症因子的影响  

Effects of Guizhifuling Capsule on Primary Dysmenorrhea Patients about Inflammation Factor

作　　者：王大为[1,2,3] 公真[1,2,3] 张蕾[1,2,3] 施建丰[1,2,3] 胡春萍[1,2,3] 曹鹏[1,2,3] 

机构地区：[1]江苏省中医药研究院 [2]南京中医药大学附属中西医结合医院 [3]中国中医科学院江苏分院

出　　处：《中国临床药理学与治疗学》2016年第4期441-444,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：中国中医科学院江苏分院课题(JSBN1303);江苏省中医药管理局科技项目(LZ13069);江苏省中医药管理局康缘中医药科技创新基金(HZ1014KY)

摘　　要：目的:探讨中药桂枝茯苓胶囊对原发性痛经(PD)患者的治疗作用,以及其对前列腺素、肿瘤坏死因子-α、β-内啡肽、白介素-1β和一氧化氮等炎症因子的影响。方法:收集45例PD患者,随机分为高剂量组、低剂量组和安慰剂组,每组15例,均治疗3个疗程。观察治疗前、后各组患者症状改善以及外周血炎症因子含量的变化。结果:PD患者给予桂枝茯苓胶囊治疗后,症状显著改善,并有一定的量效关系。桂枝茯苓胶囊有升高PD患者外周血前列腺素E2,降低β-内啡肽、白介素-1β和肿瘤坏死因子-α的趋势。结论:中药桂枝茯苓胶囊治疗PD有显著疗效,可能与调节外周血炎症因子含量,发挥其治疗作用有关。AIM： To observe the effects of Guizhifuling capsule on primary dysmenorrhea（ PD）patients about prostaglandin,tumor necrosis factor-α, β-endorphen, interleukin-1β, nitric oxide.METHODS： 45 patients were randomized into Guizhifuling capsule high-dose group, low-dose group and placebo group,15 cases in each group.These patients were treated for three consecutive menstrual cycles. Treatment effectiveness and inflammation factors in peripheral blood were monitored. RESULTS： Significantly improvement was found in the treatment group correlated to the dose of Guizhifuling capsule. Prostaglandin E2 was improved and β-endorphen,interleukin-1β and tumor necrosis factor-α were inhibited. CONCLUSION：Guizhifuling capsule has remarkable curative effects on PD and these may be related with the mediation of inflammation factor.

关 键 词：原发性痛经 桂枝茯苓胶囊 炎症因子 中药 

分 类 号：R271.113[医药卫生—中医妇科学]