联合监测PCT CRP PLT对新生儿重症感染预后的临床价值  

Clinical value of combined detection of PCT,PLT and CRP in the prognosis of ICU patients with severe infection

作　　者：杨华 巨蓉 胡旭红 

机构地区：[1]成都市妇女儿童中心医院新生儿重症医学科,四川成都610091

出　　处：《西部医学》2016年第5期641-644,647,共5页Medical Journal of West China

基　　金：国家自然科学基金青年基金(81401247)

摘　　要：目的探讨联合监测降钙素原（PCT）、C反应蛋白（CRP）、血小板计数（PLT）对重症感染新生儿预后判断的临床价值。方法选取2013年1月-2015年6月收治的50例重症感染新生儿,按照APACHE-II评分（急性生理与慢性健康评分）系统将新生儿分为四组,分别为次低危组、低危组、中危组、高危组。观察并记录下各组新生儿PCT、PLT、CRP水平,同时记录各PCT、PLT、CRP水平新生儿预后以及治疗情况（包括脓毒症、死亡、抗感染治疗时间以及住院时间）,统计并分析其与新生儿感染严重程度的关系。结果经重复方差分析,次低危、低危、中危、高危组新生儿PCT水平差异具有统计学意义（F=8.42,P〈0.05）;各组新生儿PLT水平差异具有统计学意义（F=11.34,P〈0.05）;各组新生儿PLT水平差异具有统计学意义（F=10.45,P〈0.05）。经重复方差分析,PCT〈5.0、5-10、〉10的新生儿脓毒症人数各组新生儿差异具有统计学意义（F=9.83,P〈0.05）;各组新生儿死亡人数差异具有统计学意义（F=8.73,P〈0.05）;各组新生儿抗感染治疗时间以及住院时间差异具有统计学意义（F=8.75、12.43,P〈0.05）。经重复方差分析,PLT〉100、50-100、〈50的新生儿脓毒症人数差异具有统计学意义（F=9.34,P〈0.05）,各组新生儿死亡人数差异具有统计学意义（F=8.65,P〈0.05）;各组新生儿抗感染治疗时间以及住院时间差异具有统计学意义（F=8.87、12.58,P〈0.05）。经重复方差分析,CRP〉100、50-100、〈50的新生儿脓毒症人数差异具有统计学意义（F=9.34,P〈0.05）,各组新生儿死亡人数差异具有统计学意义（F=8.65,P〈0.05）,各组新生儿抗感染治疗时间以及住院时间差异具有统计学意义（F=8.87、12.58,P〈0.05）。结论 PCT、CRP、PLT水平与重症感染新生儿预后密切相关,可应用于ICU重症感染新生儿预后的判断。Objective To explore and analyze the clinical value of combined monitoring of PCT,PLT and CRP in the prognosis of patients with severe ICU infection.Methods 50 patients with severe infection in our hospital from June2015 to January 2013 were divided into four groups including sub low risk group,low risk group,moderate risk group and high risk group,according to APACHE-II scoring system.The PCT（C）,PLT（platelet count）,CRP（platelet count）,（C-reactive protein）,the prognosis and treatment of patients（including sepsis,death,anti infection treatment time and hospitalization time）were observed.Results The level of PCT and PLT of sub low risk group,low risk group,moderate risk group and high risk group was significantly different（F=8.42,P〈0.05）.After repeated analysis of variance,the number of patients with PCT〈5.0,10 to 5,〉10of patients with sepsis were significantly different（F=9.83,P〈0.05）.The time of anti infection treatment and hospitalization time of the 4groups were significantly different（F=8.75,12.43,P〈0.05）.After repeated analysis of variance,The number of patients with PLT〉100,100 to 50,50（P〈0.05,F=9.34,F=8.65）were significantly different（,P〈0.05）.The time of anti infection treatment and hospitalization time were significantly different（F=8.87,12.58,P〈0.05）.After repeated analysis of variance,the number of patients with CRP〉100,100 to 〈50,50,the time of anti infection treatment and hospitalization time were significantly different（F=8.87,12.58,P〈0.05）were significantly different.Conclusion CRP,PLT,PCT levels are closely related to the prognosis of patients with severe infection,and can be used to determine the prognosis of patients with severe ICU infection.

关 键 词：降钙素原 C反应蛋白 血小板计数 重症感染 预后判断 

分 类 号：R722.13[医药卫生—儿科]