肺肠同治法对慢性阻塞性肺疾病急性加重期肺热腑实证患者炎症指标及肺功能的影响  

Effect of the method of treating lung and intestine simultaneously for the inflammatory indicators and lung function of patients with acute exacerbation of chronic obstructive pulmonary diseases with syndrome of excessive fu-viscera caused by lung-heat

作　　者：邵娜[1,2] 蔡琦玲[2] 袁连方[2] 

机构地区：[1]天津中医药大学,天津300000 [2]天津市南开医院呼吸内科,天津300100

出　　处：《中国医药导报》2016年第13期81-84,89,共5页China Medical Herald

基　　金：天津市卫生和计划生育委员会中医中西医结合科研课题(2015026)

摘　　要：目的探讨肺肠同治法对慢性阻塞性肺疾病急性加重期（AECOPD）肺热腑实证患者炎症指标及肺功能的影响。方法选取2014年1月~2015年7月于天津市南开医院呼吸内科住院的AECOPD肺热腑实证患者80例,采用随机数字表法将其分为治疗组和对照组,各40例。两组均给予常规治疗,治疗组同时加用肺肠同治代表方剂宣白承气汤口服,疗程为7 d。分别于治疗前及治疗后第2、5、7天测定体温、白细胞计数（WBC）、中性粒细胞百分比（N%）、C反应蛋白（CRP）,并比较两组住院天数、临床疗效,以及治疗前后肺功能和血气分析情况。结果治疗组总有效率为92.5%,对照组总有效率为82.5%,治疗组明显高于对照组,差异有统计学意义（P〈0.05）。两组治疗后体温、WBC、N%、CRP均较治疗前显著好转,差异均有统计学意义（P〈0.05）,且治疗组明显优于对照组（P〈0.05）。治疗组住院天数[（11.12±1.78）d]明显短于对照组[（13.76±1.31）d],差异有统计学意义（P〈0.05）。两组治疗后第1秒用力呼气量（FEV_1）、FEV_1占预计值的百分比、FEV_1/用力肺活量（FVC）、FVC均较治疗前显著改善,差异均有统计学意义（均P〈0.05）,且治疗组治疗后FEV_1、FEV_1占预计值的百分比明显优于对照组,差异有统计学意义（P〈0.05）。两组治疗后p H值、动脉血氧分压、动脉血二氧化碳分压均较治疗前显著改善,差异均有统计学意义（均P〈0.05）,且治疗组治疗后优于对照组（P〈0.05或P〈0.01）。结论肺肠同治法可以减轻AECOPD肺热腑实证患者炎性反应,改善临床症状,减少住院天数,提高肺功能,临床疗效较好。Objective To investigate the effect of the method of treating lung and intestine simultaneously for the inflammatory indicators and lung function of patients with acute exacerbation of chronic obstructive pulmonary diseases（AECOPD） with syndrome of excessive fu-viscera caused by lung-heat. Methods Eighty cases of patients with AECOPD with syndrome of excessive fu-viscera caused by lung-heat hospitalized in Department of Respiratory Medicine,Nankai Hospital of Tianjin City from January 2014 to July 2015 were chosen, and they were divided into treatment group and control group by random number table, with 40 cases in each group. Both groups were given conventional therapy, the treatment group was added with representative prescription of treating lung and intestine simultaneously：Xuanbai Chengqi Decoction, orally, 7 d was as a course. The temperature, white blood cell（WBC）, percentage of neutrophils（N%）, C reactive protein（CRP） before treatment and after treatment for 2, 5, 7 days in the two groups were detected, the length of stay, clinical effect, lung function and blood gas analysis before and after treatment in the two groups were compared. Results The total effective rate of treatment group was 92.5%, which of control group was82.5%, the treatment group was higher than the control group, the difference was statistically significant（P〈0.05）. The temperature, WBC, N%, CRP of the two groups after treatment were all better than those before treatment, the differences were all statistically significant（P〈0.05）, and the treatment group was better than those of control group（P〈0.05）. The length of stay in the treatment group [（11.12±1.78） d] was shorter than that of control group [（13.76±1.31） d], the difference was statistically significant（P〈0.05）. The forced expiratory volume in first second（FEV_1）, percentage of FEV_1 accounted for predicated value, FEV_1/forced vital capacity（FVC）, FVC of the two groups after treatment were all better than those before

关 键 词：肺肠同治法 宣白承气汤 慢性阻塞性肺疾病急性加重期 肺热腑实证 炎症指标 肺功能 

分 类 号：R563[医药卫生—呼吸系统]