氟桂利嗪预防性治疗前庭性偏头痛眩晕发作的前瞻性随机对照研究  

Flunarizine in the prophylaxis of vestibular migraine:a randomized controlled trial

作　　者：袁庆[1] 刘得龙[1] 余力生[2] 张庆丰[1] 

机构地区：[1]大连市中心医院耳鼻咽喉科,辽宁大连116033 [2]北京大学人民医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第10期805-810,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨盐酸氟桂利嗪在前庭性偏头痛(VM)预防性治疗中的有效性及安全性。方法:筛选需要进行预防性治疗的VM患者,将同意参与试验的患者随机分为甲、乙2组,建议所有患者进行生活方式的改变,甲组给予盐酸氟桂利嗪10mg每日睡前口服,连续用药3个月,在眩晕发作时口服甲磺酸倍他司汀片,12mg,3次/d,持续用药48h对症治疗;乙组仅在眩晕发作时口服甲磺酸倍他司汀片,12mg,3次/d,持续用药48h对症治疗。治疗开始及治疗3个月后分别记录患者治疗前后3个月眩晕发作次数、累计发作天数、眩晕发作强度,对比2组不同方案对患者上述3项指标的影响,并纪录不良事件发生情况。结果:23例VM患者完成随访,3个月后甲、乙2组患者的累计眩晕发作次数和累计眩晕天数均减少(P<0.05),眩晕发作强度均减轻(P<0.05);与乙组相比,甲组使用氟桂利嗪后能更加有效减少患者眩晕发作次数(P<0.05),但对减少累计眩晕天数、眩晕发作强度的影响与乙组差异无统计学意义(P>0.05)。未发现严重不良事件。结论:氟桂利嗪对于VM的预防安全、有效。Objective：To evaluate the efficacy and safety of flunarizine in patients with vestibular migraine（VM）as a prophylactic medication.Method：This randomized control trial was undertaken in patients with definite VM.Behavior changes were advocated to all the patients to avoide certain foods and beverages,as well as changes in lifestyle and habits.Patients in arm A received 10-mg flunarizine daily for 3months along with betahistine 12 mg Tid for 48 hduring episodes,and arm B received only betahistine for 48 hduring episodes.Frequency.duration and intensity of vertiginous episodes and the main side-effects were noted at the start of the study and at the end of 3months.Result：A total of 23 patients who were diagnosed with definitive migrainous vertigo completed the study.The frequency,duration and intensity of vertiginous episodes showed a significan improvement in both group（P〈0.05）.Analysis of the frequency,duration and intensity between arm A and arm B showed that frequency improved to a significant degree（P〉0.05）,but the duration and intensity of vertigo between the two groups did not improve to a significant degree（0.05）.Severe adverse events were not found.Conclusion：Flunarizine is safe and effective for the prophylaxis treatment of VM.

关 键 词：氟桂利嗪 前庭性偏头痛 预防性治疗 

分 类 号：R441.2[医药卫生—诊断学]