急、慢性布鲁杆菌病患者肝功能损伤特点及肝功能指标检验对比研究  

The comparative study of characteristics of hepatic injury and index inspection of liver function of the patients with acute and chronic brucellosis

作　　者：左凯[1] 孔丽[2] 马龙[3] 谢琳琳[1] 李文玉[1] 

机构地区：[1]滨州市人民医院感染二科,山东滨州256600 [2]滨州市人民医院静配室,山东滨州256600 [3]滨州市人民医院急救站,山东滨州256600

出　　处：《中国地方病防治》2016年第4期367-369,共3页Chinese Journal of Control of Endemic Diseases

基　　金：山东省自然科学基金资助项目(ZR2012HL36)

摘　　要：目的分析研究急、慢性布鲁杆菌病患者肝功能损伤特点以及肝功能指标检验结果对比,以增加医护人员对急、慢性布鲁杆菌病及其肝脏并发症的认识。方法 66例布鲁杆菌病患者,将34例急性布鲁杆菌病患者设为观察组,32例慢性布鲁杆菌病患者设为对照组,对比观察布鲁杆菌病患者肝功能检测结果与参考值差异、两组患者血清ALP、AST、ALT、白蛋白、结合胆红素、总胆红素、总蛋白、白蛋白/球蛋白、γ-谷氨酰基转移酶等肝功能指标及治疗前后肝功能异常情况对比。结果布鲁杆菌病患者血清ALP、AST、ALT、ALB、DBIL、TBIL、TP、γ-GT与参考值比较,差异有统计学意义(P<0.05);A/G与参考值比较差异无统计学意义(P>0.05);观察组血清ALP、AST、ALT、ALB、DBIL、TBIL、TP、γ-GT、A/G与对照组比较,差异均无统计学意义(P>0.05);经治疗,两组患者GIb升高、AIb降低、ALP增高、γ-GT增高、AST增高、ALT增高率与治疗前比较,差异均有统计学意义(P<0.05),TBIL增高与治疗前比较差异无统计学意义(P>0.05)。结论布鲁杆菌病患者肝功能均出现不同程度损伤,并且受损程度较为轻微,急性布鲁杆菌病患者肝功能各项指标受损程度与慢性布鲁杆菌病患者比较无显著差异,并且经治疗后各项指标可基本恢复正常水平。Objective To analytical investigate the characteristics of hepatic injury and comparison of index inspection of liver function of the patients with acute and chronic brucellosis,for increasing the cognition of the medical workers of the acute and chronic brucellosis and liver complications.Methods To extracted 66 cases of patients with brucellosis at our hospital from June,2013 to July,2015 as the object of study,the 34 cases of the patients with acute brucellosis as the treatment group,and the 32 cases of the patients with chronic brucellosis as the control group.To compared the detection result and difference of reference value of the liver function of them.To compared the serum ALP,AST,ALT,albumin,direct bilirubin,total bilirubin,total protein,albumin/globulin,gamma-glutamyltransferase and other liver function index and the abnormal liver function of the pretherapy and post-treatment of them.Results Reduce GIb brucellosis patients serum ALP,AST,alt,ALB,DBIL and TBIL,TP,gamma GT and the reference value,the difference was statistically significant(P<0.05);a/g and the reference value of the difference was not statistically significant(P>0.05);observation group,the serum levels of ALP,AST,alt,ALB,DBIL and TBIL,TP,gamma GT,a/g and the control group,the difference had no statistical significance(P>0.05).After the treatment,the two groups of patients increased and AIB,ALP increased,gamma GT increased,elevated AST and ALT increased rate and treatment of comparison,the differences were statistically significant(P<0.05),TBIL increased before treatment difference was not statistically significant(P>0.05).Conclusion That has the different degree of the damage of the all the indexes of liver function of the patients with the bilirubin,and the extent of damage was slight.To compared the extent of damage of the liver function of the patients with acute brucellosis and chronic brucellosis,there was no statistical significance,and all the indexes are almost recovered to normal after treatment.

关 键 词：急性布鲁杆菌病 慢性布鲁杆菌病 肝功能损伤特点 肝功能指标 

分 类 号：R516.7[医药卫生—内科学]