盐酸特拉唑嗪降解产物的结构鉴定  

Structure characterization of the degradation products of terazosin hydrochloride

作　　者：孙玉明[1] 李英[1] 王月月[1] 张华[1] 王玉林[2] 

机构地区：[1]大连理工大学化工学院,辽宁大连116024 [2]大连医科大学基础医学院,辽宁大连116044

出　　处：《色谱》2016年第5期490-497,共8页Chinese Journal of Chromatography

摘　　要：盐酸特拉唑嗪是一种新型选择性α_1-肾上腺能受体拮抗剂,用于治疗高血压和良性前列腺增生。采用高效液相色谱-高分辨多级质谱(HPLC-HRMS^n)联用法对强氧化条件下盐酸特拉唑嗪原料药的降解产物进行了详细的解析和结构确证。共检测到15种降解产物,其中7种与文献报道的有关物质相同,另外8种为新检测到的降解产物,其主要降解途径为酰胺键水解、羟基化、羰基化及3种途径组合的次级降解途径。Terazosin hydrochloride is a selective α_1-adrenergic blocker used in the treatment of hypertension and benign prostatic hyperplasia. A high performance liquid chromatographymultistage mass spectrometry with high resolution（HPLC-HRMS-n）method was used to detect and identify the degradation products of terazosin hydrochloride treated under stressed oxidation condition. There were 15 degradation products detected. Seven of them were the same as those found in the related references,and the other eight of them were newly found and identified. The main degradation pathways are the hydrolysis of amide bond,hydroxylation,carbonylation and secondary degradation pathways by the combination of the above three ways.

关 键 词：高效液相色谱-高分辨多级质谱 结构鉴定 降解产物 盐酸特拉唑嗪 

分 类 号：O658[理学—分析化学]