[C3H(12)N2]3[P2Mo5O(23)]·4H2O单晶体的水热合成及其催化合成阿司匹林的研究  

Hydrothermal Synthesis of [C_3H_(12)N_2]_3[P_2Mo_5O_(23)]·4H_2O Single Crystal and Its Catalytic Performance on Synthesis of Aspirin

作　　者：张羽男[1] 张大俊[1] 刘立新[1] 张向宇[1] 冯艳茹[1] 沙靖全[1] 张云杰[1] 王朝兴[1] 沈宇[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《广东化工》2016年第10期17-18,4,共3页Guangdong Chemical Industry

基　　金：佳木斯大学青年科学基金项目(Lq2012-49);中国博士后科学基金资助项目(2014M 561382)

摘　　要：利用水热法制备了单晶体化合物[C_3H_(12)N_2]_3[P_2Mo_5O_(23)]·4H_2O(1),并通过单晶X-射线衍射和元素分析对其进行了结构表征。通过正交试验对其催化合成阿司匹林的性能进行了初步研究,确定了其催化合成阿司匹林的最佳条件:催化剂用量0.15 g,反应时间为30 min,反应温度85℃。表明该单晶体化合物可以替代传统催化剂浓硫酸合成阿司匹林,有望成为未来绿色制药工业的新型催化剂。[CaH12N213 [P2Mo5O23]·4H2O single crystal has been synthesized by hydrothermal synthesis method, and its catalytic performance on systhesis of Aspirin have been studied by orthogonal experimental. The best experimental condition tbr synthesis of Aspirin by [CaH12N213 [P2Mo5O23]·4H2O has been determined： catalyst dose is 0.15 g, time is 30 rain, temperature is 85 ℃. The results showed that [CaH12N213 [P2Mo5O23]·4H2O single crystal could replace concentrated sulfuric-acid to catalyze systhesis of Aspirin, which is expected to become the new future catalyst in green phamaceutical industry.

关 键 词：磷钼氧簇 单晶体化合物 催化 阿司匹林 

分 类 号：TQ225.241[化学工程—有机化工]