白芍总苷微孔渗透泵片的研制及体外同步释放性研究  

Preparation and Synchronized Release Behavior on Porosity Osmotic Pump Tablets of Total Glucosides of Paeony

作　　者：吴先闯[1] 郝海军[2] 宋晓勇[1] 刘瑜新[1] 张永州[1] 张红芹 

机构地区：[1]河南大学淮河医院药学部,河南开封475000 [2]上海医药工业研究院,上海200437 [3]国家中药制药工程技术研究中心,上海201203

出　　处：《中药材》2016年第2期363-366,共4页Journal of Chinese Medicinal Materials

基　　金：河南省科技发展计划项目(144300510019);开封市科技发展计划项目(1403024)

摘　　要：目的:研制白芍总苷微孔渗透泵片,考察白芍总苷微孔渗透泵片主要成分体外释药的同步性。方法:以白芍总苷累积释放度为指标,分别采用单因素及正交试验得到白芍总苷微孔渗透泵片的最佳处方。以芍药苷、芍药内酯苷、苯甲酰芍药苷的释放度为指标,考察最佳处方中3个主成分的同步释放性。结果:衣膜增重、衣膜中PEG 400及邻苯二甲酸二乙酯的用量是影响药物释放行为的主要因素。优化后的微孔渗透泵片中白芍总苷累积释放度约为90%,3个主成分呈良好的零级释放特征,同步释放性较好。结论:制备的白芍总苷微孔渗透泵片重复性较好,可以实现其多组分同步释放。Objective: To prepare porosity osmotic pump tablets of total glucosides of paeony( TGP),and to study the behavior on synchronous release of its main components. Methods: Taking the accumulative release of TGP as indexes,through single-factor test and orthogonal design to investigate the optimal formulation porosity osmotic pump tablets of TGP. The main components,paeoniflorin,albiflorin and benzoylpaeoniflorin were employed to study synchronous release of the optimal formulation. Results: The membrane weight,and the content of PEG 400,and diethyl phthalate( DEP) were the main factors influencing the behavior of TGP release. The accumulated release of the prepared osmotic pump release tablets achieved about 90%. Three main components achieved the desired zero-order release profile and had a synchronized release behavior. Conclusion: The prepared porosity osmotic pump tablets of TGP can achieve the behavior of synchronized release of multi-components with good reproducibility.

关 键 词：白芍总苷 微孔渗透泵片 同步释放 

分 类 号：R286.3[医药卫生—中药学]