不同氧浓度对体外受精-胚胎移植妊娠结局的影响  

Effect of oxygen concentration on the outcome of human in vitro fertilization and embryo transfer

作　　者：罗丹[1] 高颖[1] 丁晓芳[1] 舒德峰[1] 朱燕[1] 李璐璐[1] 钟少红[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院生殖中心,武汉430022

出　　处：《中国性科学》2016年第5期118-120,共3页Chinese Journal of Human Sexuality

摘　　要：目的:探讨体外培养时不同氧浓度对体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)中胚胎发育潜能及妊娠结局的影响。方法:将471例于2013年在本生殖中心行IVF-ET的患者,根据其体外培养的氧浓度将其随机分为5%低氧浓度组(n=247)和20%高氧浓度组(n=224)。比较两组间卵子成熟率、受精率、卵裂率、正常受精率、多PN率、D3优质胚胎率、囊胚形成率、可利用胚胎率、临床妊娠率、着床率及活产率。结果:两组间患者的卵子成熟率、受精率、卵裂率、正常受精率、多PN率、D3优质胚胎率、囊胚形成率、可利用胚胎率、临床妊娠率、着床率均无统计学差异(P>0.05)。但低氧浓度组的活产率显著高于高氧浓度组(48.2%vs.38.4%,P<0.05)。结论:低氧浓度胚胎培养能够改善IVF的妊娠结局。Objectives： To evaluate the effect of different oxygen concentration on the outcome of in vitro fertilization（ IVF）. Methods： 471 women undergoing IVF were randomly divided into 5% oxygen concentration group（ n = 247） and 20% oxygen concentration group（ n = 224）. The rates of mature oocytes,fertilization,cleavage,normal fertilization,multiple pronuclei,good quality embryo,blastocyst formation,embryo utilization,clinical pregnancy,implantation and live birth were compared. Results： The live birth rate was significantly higher in the5% oxygen concentration group（ 48. 2% vs. 38. 4%,P〈0. 05）. However,no significant differences were found between the two groups in the other rates（ P〉0. 05）. Conclusion： The improvement in live birth rate indicates that the use of lower oxygen concentration may be more suitable for IVF cycles.

关 键 词：氧浓度 体外受精 胚胎移植 活产率 

分 类 号：R697[医药卫生—泌尿科学]