脑实质囊虫病亚临床期的1H-MRS成像研究  

1H magnetic resonance spectroscopy studies on subclinical neurocysticercosis

作　　者：王青[1] 张承志[1] 李信响 徐鲲[1] 苏洁[1] 

机构地区：[1]大理学院附属医院放射科,大理671000

出　　处：《磁共振成像》2016年第5期365-370,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81060225)~~

摘　　要：目的应用单体素1H-MRS波谱成像前瞻性研究对其脑实质囊虫病亚临床期的诊断价值。材料与方法筛选110例脑实质囊虫病亚临床期为研究对象,并与130例脑实质囊虫病活虫期为对照,进行单体素^1H-MRS波谱成像检查,观测脑实质囊虫（亚临床期）病灶及其周围区域某些微量代谢产物比值的变化,并进行对照评价。结果脑实质囊虫病亚临床期与正常镜像区组各生化代谢物比值结果均无显著性差异;脑实质囊虫病亚临床期组与活虫期组统计学分析评价,其中NAA/Cho比值、Cho/Cr比值及Lip/Cr比值有差异性统计学意义,NAA/Cho比值高于活虫期组,Cho/Cr比值及Lip/Cr比值均低于活虫期组,并选择NAA/Cho比值及Lip/Cr比值应用ROC曲线分析评价脑实质囊虫病亚临床期与活虫期鉴别诊断效能。结论揭示脑实质囊虫病亚临床期和活虫期病灶^1H-MRS波谱变化特征及其变化规律,制定出相应的NAA/Cho比值及Lip/Cr比值诊断指标,对于早期诊断及早治疗具有非常重要的指导意义。Objective： To evaluate the clinical application of single voxel 1H magnetic resonance spectroscopy in diagnosis of subclinical neurocysticercosis.Materials and Methods： One hundred and ten cases of subclinical neurocysticercosis and 130 cases of cerebral cysticercosis（live worms stage） with contrast enhanced single voxel 1H magnetic resonance spectroscopy were screened for this study.Observation of the change in ratio of the lesions of the subclinical neurocysticercosis and some trace metabolites around the lesions was done. Results： The group of subclinical neurocysticercosis has no significant difference with normal control group in various biochemical metabolites. The ratios of NAA/Cho, Cho/Cr and Lip/Cr have statistical significance in the analysis and evaluation of subclinical neurocysticercosis group and live worms stage group. The ratio of NAA/Cho in subclinical neurocysticercosis group is higher than live worms stage group. The ratios of Cho/Cr and Lip/Cr of the former are lower than that of the latter. The ratios of NAA/Cho and Lip/Cr evaluate the differential diagnosis efficiency between subclinical neurocysticercosis stage and live worms stage on ROC curve. Conclusions： 1H-MRS reveals the changes in characteristics of subclinical neurocysticercosis stage and live worms stage so as to evaluate the corresponding diagnosis index of the ratios of NAA/Cho and Lip/Cr, which are of great value to early diagnosis and treatment of the neurocysticercosis.

关 键 词：神经系统囊虫病 脑疾病 磁共振波谱学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]