唐古特白刺叶的化学成分研究  

Chemical constituents from leaves of Nitraria tangutorum

作　　者：赵建强[1,3] 辛海量[2] 蒋益萍[2] 梅丽娟[1] 陶燕铎[1] 

机构地区：[1]中国科学院西北高原生物研究所,中国科学院藏药研究重点实验室,青海西宁810008 [2]中国人民解放军第二军医大学药学院生药学教研室,上海200433 [3]中国科学院大学,北京100049

出　　处：《中草药》2016年第7期1090-1093,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然基金联合项目(U1203104);青海省重大科技专项(2014-GX-A3A)

摘　　要：目的对唐古特白刺Nitraria tangutorum叶的化学成分进行研究。方法采用溶剂萃取,反复硅胶柱色谱和制备液相色谱等方法进行分离纯化,根据理化性质及核磁数据鉴定化合物的结构。结果从唐古特白刺叶的95%乙醇提取物中分离得到9个化合物,分别鉴定为4-氧代-β-紫罗兰醇-β-D-吡喃葡萄糖苷（1）、（6R,9R）-3-氧代-α-紫罗兰醇-β-D-吡喃葡萄糖苷（2）、blumenyl Cβ-D-glucopyranoside（3）、blumenyl Aβ-D-glucopyranoside（4）、丁香树脂酚-4′-O-β-D-吡喃葡萄糖苷（5）、citrusin B（6）、nikoenoside（7）、2-苯乙基-O-β-D-吡喃葡萄糖苷（8）和吲哚-3-乙基-β-D-吡喃葡萄糖苷（9）。结论化合物1~9均为首次从该属植物中分离得到,其中,化合物9的13C-NMR数据为首次报道。Objective To study the chemical constituents from the leaves of Nitraria tangutorum. Methods The chemical constituents were isolated by solvent extraction, repeated silica gel chromatography, and preparative-HPLC. Their structures were elucidated by physicochemical properties and 1H-NMR and 13C-NMR data. Results Nine compounds were isolated from the ethanol extract of the leaves of N. tangutorum and their structures were identified as 4-oxo-β-ionol β-D-glycopyranoside（1）,（6R,9R）-3-oxo-α-ionol β-D-glycopyranoside（2）, blumenyl C β-D-glucopyranoside（3）, blumenyl A β-D-glucopyranoside（4）, syringaresinol- 4′-O-β-D-glucopyranoside（5）, citrusin B（6）, nikoenoside（7）, 2-phenylethyl-β-D-glucopyranoside（8） and indole-3-ethyl-β-D-glucopyranoside（9）. Conclusion All the isolates are reported from the plants of Nitraria L. for the first time and the 13C-NMR data of compound 9 are also reported for the first time.

关 键 词：唐古特白刺 4-氧代-β-紫罗兰醇-β-D-吡喃葡萄糖苷 citrusin B nikoenoside 吲哚-3-乙基-β-D-吡喃葡萄糖苷 

分 类 号：R284.1[医药卫生—中药学]