四种活血化瘀类中药注射液寒热药性的比较  

Comparison of four herb injections promoting blood circulation for removing blood stasis on cold and heat properties

作　　者：赵珊珊[1] 郝艳玲[2] 袁凤刚[2] 贾先红[1] 毛承飞[1] 周钦荣[1] 朱红梅[1] 

机构地区：[1]徐州医学院附属医院,江苏徐州221000 [2]徐州医学院,江苏徐州221000

出　　处：《中成药》2016年第5期973-978,共6页Chinese Traditional Patent Medicine

基　　金：徐州市科技局基金资助项目(KC14SH109)

摘　　要：目的探讨四种临床常用活血化瘀类中药注射液的寒热药性差异。方法将88只SD大鼠随机分为3组,正常对照组(n=8)、寒凝血瘀证实验组(SCCBS,n=40)和瘀热互结证实验组(SHBS,n=40)。两实验组各自再分为5小组(红花黄色素组、大株红景天组、丹参川芎嗪组、血塞通组、对照组)。各给药组大鼠在造模同时给药,每天1次,持续14 d,对照组大鼠给予等量的生理盐水。结果大株红景天注射液在寒凝血瘀证中,可使大鼠的血流变学指标、内皮素(ET)、一氧化氮(NO)改善(P<0.05,P<0.01),肾上腺素(ADR)、促甲状腺素(TSH)升高(P<0.01);而在瘀热互结证中,各指标无明显变化(P>0.05)。注射用红花黄色素在寒凝血瘀证及瘀热互结证中,均可使大鼠的血流变学指标、ET、NO改善(P<0.05,P<0.01),但ADR、TSH均无明显变化(P>0.05)。丹参川芎嗪注射液在瘀热互结证中,可使大鼠的血流变学指标、ET、NO改善(P<0.05,P<0.01),ADR、TSH下降(P<0.01);而在寒凝血瘀证中,仅血流变学中红细胞聚集指数改善(P<0.05)。注射用血塞通(冻干)在瘀热互结证中,可使大鼠的部分血流变学指标、ET、NO改善(P<0.05,P<0.01);而在寒凝血瘀证中,仅血流变学中红细胞聚集指数可见改善(P<0.05),两证中ADR、TSH均无明显变化(P>0.05)。结论大株红景天注射液药性偏温,丹参川芎嗪注射液药性偏寒,注射用红花黄色素、注射用血塞通药性相对较平和。AIM To study the differences of cool-heat properties of four herb injections promoting blood circulation for removing blood stasis on cold and heat properties. METHODS Eighty-eight SD rats were randomly divided into three groups,control group（ n = 8）,treatment group with syndrome of cold congelation and blood stasis（ SCCBS）（ n = 40） and treatment group with syndrome of heat and blood stasis（ SHBS）（ n = 40）. The latter two groups were again divided into five subgroups,sham group and four drug groups. Rats in the drug groups were administrated with different drugs accompanying modeling,once a day,for fourteen days. Rats in the sham group were injected with the same dose of normal saline. RESULTS For SCCBS,Sofren Injection improved hemorheology indexes,endothelin（ ET）,nitric oxide（ NO）（ P〈0. 05,P〈0. 01）,and increased epinephrine（ ADR）,thyroid stimulating hormone（ TSH）（ P〈0. 01）; however,there was no change for SHBS（ P〈0. 05）. Safflower Yellow Injection could improve hemorheology indexes,ET and NO for both SCCBS and SHBS（ P〈0. 05,P〈0. 01）,but it did not influence ADR and TSH（ P〈0. 05）. Danshen Ligustrazine Injection could improve hemorheology indexes,ET,NO（ P〈0. 05,P〈0. 01）,and reduced ADR,TSH（ P〈0. 01） for SHBS,while only red cell assembling index was reduced for SCCBS（ P〈0. 05）. Xuesaitong Injection could improve part of hemorheology indexes,ET,NO（ P〈0. 05,P〈0. 01） for SHBS,only red cell assembling index was improved for SCCBS（ P〈0. 05）. There was no change for ADR or TSH（ P〈0. 05）. CONCLUSION Property of Sofren Injection is heat,while Danshen Ligustrazine Injection is cool,Safflower Yellow Injection and Xuesaitong Injection are relatively moderate.

关 键 词：注射用红花黄色素 大株红景天注射液 丹参川芎嗪注射液 注射用血塞通(冻干) 活血化瘀 寒凝血瘀证 瘀热互结证 大鼠 

分 类 号：R285.5[医药卫生—中药学]