生、麸炒苍术对痰湿困脾模型大鼠治疗效果  

Therapeutic effect of Atractylodis Rhizoma processed with and without stir-frying with bran on rats with spleen disorder due to dampness

作　　者：许晨曦[1] 刘玉强[1] 刘阳芷 贾蕊[1] 才谦[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中成药》2016年第5期978-983,共6页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局中医药行业科研专项项目(20110700712);国家自然科学基金资助项目(81202919;81573601)

摘　　要：目的探究苍术麸炒前后对痰湿困脾模型大鼠的治疗作用。方法以饮食不节、潮湿环境、强迫游泳方法建立痰湿困脾模型大鼠,分别口服生、麸炒苍术以及平胃散,用ELISA法测量不同组别大鼠给药后消化道水通道蛋白2(AQP2)、水通道蛋白3(AQP3)以及血清抗利尿激素(ADH)、胃泌素(GAS)、淀粉酶(AMS)活性和肠管含水量等指标。结果生、麸炒苍术均使造模大鼠大肠肠管含水量下降,血清GAS含有量以及AMS上升,但麸炒苍术在恢复消化道AQP2和AQP3含有量,以及血清ADH含有量方面优于生苍术。结论麸炒有提升苍术治疗大鼠痰湿困脾的作用。AIM To study the effects of Atractylodis Rhizoma procesed with and without stir-frying with bran on rats with spleen disorder due to dampness. METHODS The rat model for spleen disorder due to dampness was established by improper diet,damp environment and forced swimming. Modeled rats were then orally administered Atractylodis Rhizoma processed with and without stir-frying with bran and Pingwei Powder. Their AQP2 levels in large intestine,AQP3 levels in stomach and levels of ADH,GAS and AMS in serum were measured by ELISA.Their moisture contents of large intestine were also measured. RESULTS Atractylodis Rhizoma processed with and without stir-frying with bran made the moisture content in large intestine decrease and GAS level in serum and AMS increase in modeled rats. But Atractylodis Rhizoma processed with stir-frying with bran decreased more AQP2 and AQP3 levels in stomach,and ADH level in serum than it without stir-frying with bran did. CONCLUSION Stir-frying with bran can markedly improve Atractylodis Rhizoma＇s therapeutic effect on rats with spleen disorder due to dampness.

关 键 词：苍术 麸炒 痰湿困脾 水通道蛋白 药效学 

分 类 号：R285.5[医药卫生—中药学]