基于光学相干断层扫描冻干显微镜的设计研究  

Research on the Design of Optical Coherence Tomography-based Freeze-drying Microscope

作　　者：刘代春 张爱平[1] 于颖[1] 

机构地区：[1]中国药科大学,南京211198

出　　处：《化工与医药工程》2015年第6期40-47,共8页Chemical and Pharmaceutical Engineering

基　　金：华海药业研究生创新基金项目(CX14S-002HH)

摘　　要：根据化工设备设计的一般要求和技术规范设计冻干显微镜(FDM)装置,通过查阅文献和计算,确定相关的参数。主要从冻干箱与冷凝器的尺寸、抗压强度、传热性能等几个方面进行FDM结构设计,并与光学相干断层扫描技术(OCT)和可调谐二极管激光吸收光谱(TDLAS)相结合,尝试开发新型冻干显微镜装置,以期实现在线监测冻干小瓶内制品的显微结构、温度、真空度和水蒸气浓度。The goal of this work was to apply the general chemical equipment design requirements and technical specifications to design the freeze-drying microscope （FDM） device, and determining the relevant parameters by consulting literatures and calculation. Its structure was mainly designed from the aspects of the size of freeze-drying chamber and condenser, as well as compressive strengths and heat transfer performance, and which was combined with optical coherence tomography （OCT） and tunable diode laser absorption spectroscopy （TDLAS） technology. A novel optical coherence tomography-based freeze-drying microscope device was researched and developed, hoping that the microscopic structure, temperature, vacuum and water vapor concentration of lyophilized products in vials were monitored on line.

关 键 词：液氮 冻干显微镜 OCT TDLAS 结构设计 

分 类 号：TH742[机械工程—光学工程] TQ460.5[机械工程—仪器科学与技术]