Lp-PLA_2预测急性心梗患者PCI预后的价值  

Prognostic Value of Lipoprotein-associated Phospholipase A_2 Concentration in Patients with Acute ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

作　　者：张振[1] 王海斌 王国龙[1] 陈月婷[1] 

机构地区：[1]河北省涿州市医院心内科,072750 [2]河北任丘华北石油总医院,062550

出　　处：《临床心电学杂志》2015年第6期410-415,共6页Journal of Clinical Electrocardiology

摘　　要：目的探讨脂蛋白相关磷脂酶A_2(Lp-PLA_2)对行直接经皮冠状动脉介入治疗(PCI)的急性ST段抬高性心肌梗死(STEMI)患者预后的预测价值。方法连续入选2014年6月至2015年6月在河北省涿州市医院心内科住院治疗的首次急性心肌梗死患者共220例。入院根据PCI术前检测Lp-PLA_2水平分为高、低水平两组,随访6个月,观察住院期间及随访期间心血管事件发生情况。结果高Lp-PLA_2组在前壁心肌梗死、心功能killip≥Ⅱ分级比例、血肌酐(Cr)水平及冠脉病变支数高于低Lp-PLA_2组,左室射血分数(LVEF)明显低于低Lp-PLA_2组,6个月内预后比较有统计学意义(p<0.05)。结论脂蛋白相关磷脂酶A_2对行直接PCI的急性STEMI患者6个月内发生心血管事件的预测有一定的价值。Objective To evaluate the prognostic value of lipoprotein-associated phospholipase A2 concentration in patients with STEMI undergoing primary PCI. Methods Two hundreds and twenty consecutive patients with STEMI at Hebei Province Zhuozhou hospital were enrolled from June 2014 to June 2015. According to the Lp-PLA2 level measured immediately before the invasive procedure, the patients were divided into low Lp-PLA2 group and high Lp-PLA2 group. All of the subjects accomplished the coronary angiography （CAG）; accessed the severity of coronary artery lesions, TIMI grade and analysis of cardiac events within 6 months. Results There were statistically significant difference in anterior-wall MI, Killip≥ Ⅱ, LVEF, creatinine （Cr）, severity of coronary artery lesions and 6-month prognosis between the two groups （p〈0.05）. Conclusions Increased Lp-PLA2 predicts MACE in patients with STEMI treated with PPCI within 6-month follow up.

关 键 词：脂蛋白相关磷脂酶A_2 急性心肌梗死 预后 

分 类 号：R542.22[医药卫生—心血管疾病]