尿肾损伤分子-1与血清胱抑素C联合检测对冠状动脉介入后对比剂致急性肾损伤的早期诊断意义  

Early diagnostic value of urinary kidney injury molecule 1 and serum cystatin C levels on contrast-induced acute kidney injury after coronary intervention

作　　者：包浔娜[1] 唐方明[1] 李鸿杰[1] 叶丽冰[1] 敖伟[1] 何星球[1] 陈冠鹏[1] 王格社[1] 郑云龙[1] 

机构地区：[1]广东省农垦中心医院,广东湛江524000

出　　处：《广东医学院学报》2015年第6期667-669,共3页Journal of Guangdong Medical College

摘　　要：目的了解尿肾损伤分子-1(KIM-1)和血清胱抑素C(CysC)联合检测对冠状动脉介入后对比剂致急性肾损伤(CI-AKI)的早期诊断意义。方法 351例行冠状动脉介入患者,检测术前及术后12、24、48 h血清肌酐(Scr)和血清胱抑素C(CysC)、尿KIM-1水平,比较43例CI-AKI和43例对照者Scr、CysC、KIM-1水平。结果对照组术后Scr、CysC及KIM-1水平与术前比较,差异无统计学意义(P>0.05)。与术前及同时点对照组比较,CI-AKI组术后各时点KIM-1水平、术后24h和48 h Scr水平、以及术后24 h Cys C水平均明显升高(P<0.01或0.05)。CI-AKI组术后24 h Scr与KIM-1及CysC水平呈正相关(r值分别为0.718与0.629,均P<0.01)。结论联合检测尿KIM-1和血清CysC水平可能有助于早期诊断CI-AKI。Objective To study the early diagnostic significance of urinary kidney injury molecule 1（KIM-1） and serum cystatin C（CysC） levels in contrast-induced acute kidney injury（CI-AKI） after coronary intervention. Methods Serum levels of creatinine and CysC and urinary level of KIM-1 in 351 patients undergoing coronary intervention were detected before and 12 h,24 h,48 h after operation,and their levels were compared between 43 CI-AKI cases and 43 controls. Results Levels of creatinine,CysC and KIM-1 showed no difference before and after operation in control group（P〈0.05）. KIM-1 content at all timepoints,creatinine content at 24 h and 48 h,and CysC content at 24 h after operation in CI-AKI group were higher than those before operation in CI-AKI group and same timepoints in control group（P〈0.01 or 0.05）. Creatinine level was positively correlated with KIM-1（r=0.718,P〈0.01） and CysC（r=0.629,P〈0.01） 24 h after operation in CI-AKI group. Conclusion Combined detection of urinary KIM-1 and serum Cys C levels may be helpful for early diagnosis of CI-AKI.

关 键 词：对比剂致急性肾损伤 肾损伤分子1 胱抑素C 

分 类 号：R692[医药卫生—泌尿科学]