诺雷德对妇科肿瘤术后化疗患者卵巢功能的影响  

Effect of zoladex on ovarian function in patients with gynecological cancer undergoing postoperative chemotherapy

作　　者：陈文慧[1] 柯晓燕[2] 潘敏[1] 

机构地区：[1]广东省茂名市人民医院妇科,广东茂名525000 [2]广州中医药大学附属第一医院,广东广州510405

出　　处：《广东医学院学报》2015年第6期673-675,共3页Journal of Guangdong Medical College

摘　　要：目的了解诺雷德对宫颈癌或卵巢癌术后化疗患者卵巢功能的影响。方法 108例术中保留子宫及一侧附件的宫颈癌或卵巢癌患者随机分成2组。常规组用紫杉醇+卡铂或博来霉素+依托泊苷+顺铂化疗,诺雷德组在化疗基础上加用诺雷德。比较两组月经情况、妊娠、更年期相关症状及性激素变化。结果与常规组比较,诺雷德组月经复潮时间缩短,妊娠率高,更年期相关症状明显减轻(P<0.01),两组间性激素水平差异有统计学意义(P<0.01)。结论诺雷德可有效保护宫颈癌或卵巢癌患者卵巢功能,提高妊娠率及生活质量。Objective To investigate the effect of zoladex on the ovarian function in patients with cervical or ovarian cancer undergoing postoperative chemotherapy. Methods A total of 108 patients with cervical or ovarian cancer who underwent the preservation of the uterus and single adnexa were randomized to 2 groups：conventional group received the regimen of paclitaxel＋carboplatin or bleomycin＋etoposide＋cisplatin,while zoladex group accepted the above regimen and zoladex. The menstrual flow,pregnancy,climacteric symptoms and serum levels of sex hormones were compared in both groups. Results Compared with conventional group,the resumed time of menses and climacteric symptoms decreased and pregnancy rate increased in zoladex group（P〈0.01）. Serum levels of sex hormones showed significant differences between both groups（P〈0.01）. Conclusion Zoladex could effectively protect the ovarian function and improve the rate of pregnancy and quality of life in patients with cervical or ovarian cancer.

关 键 词：宫颈癌 卵巢癌 诺雷德 化学治疗 

分 类 号：R71[医药卫生—妇产科学]