首发广泛性焦虑障碍患者认知功能特点  

The Characteristic of Cognitive Function in Patients with the First-episode Generalized Anxiety Disorder

作　　者：叶刚[1] 汤臻[1] 李歆[2] 潘明志[1] 朱峰[1] 付佳林 伏天 刘期春 高振勇[1] 

机构地区：[1]江苏省苏州市广济医院,215000 [2]苏州大学

出　　处：《中国健康心理学杂志》2016年第5期650-654,共5页China Journal of Health Psychology

基　　金：苏州市2014年度科技发展计划(编号:SYSD2014132)

摘　　要：目的:探讨首发广泛性焦虑障碍患者认知功能的特点。方法:应用广泛性焦虑障碍量表(GAD-7)、状态-特质焦虑问卷(STAI)、剑桥神经心理自动化成套测试软件(CANTAB)中RVP、DMS、IED 3项测验对48名首发广泛性焦虑障碍患者及48名正常对照施测,分析两组被试注意能力、工作记忆能力、执行功能的差异,并了解上述认知功能和总体焦虑水平、状态焦虑、特质焦虑的相关性。结果:首发广泛性焦虑障碍组RVP测验正确率显著低于对照组(t=-4.38,P<0.05),平均反应时显著长于对照组(t=4.66,P<0.05);DMS测验中多项延迟测试任务正确数都显著低于对照组(t=-6.31^-3.62,P<0.05),平均反应时都显著长于对照组(t=3.45~4.17,P<0.05);IED测验中总错误数(t=3.33,P<0.05)、外维转换错误数(t=2.48,P<0.05)、完成测试数(t=2.59,P<0.05)显著大于对照组。首发广泛性焦虑障碍组DMS多项延迟测试反应时、IED外维转换错误数与GAD-7、SAI、TAI得分呈显著正相关(P<0.05),RVP正确率与GAD-7、SAI得分成呈显著负相关(P<0.05)。结论:首发广泛性焦虑障碍患者存在多项认知功能异常。Objective：To study the characteristic of cognitive function in patients with the first-episode generalized anxiety disorder.Methods：48 patients with the first-episode generalized anxiety disorder and 48 healthy subjects （control group）were recruited.Generalized Anxiety Disorder Scale（GAD-7）and State-Trait Anxiety Inventory （STAI）were used to assess the levels of overall anxiety,state anxiety and trait anxiety.Rapid Visual Information Processing （RVP）,Delayed Matching To Sample（DMS）and Intra/Extradimensional Set Shift（IED）from Cambridge Neuropsychological Test Automatic Battery（CANTAB）were administered to assess the characteristic of attention, working memory and executive function,analysis of variance and covariance were conducted.Results：Compared with normal controls,patients with the first-episode generalized anxiety disorder had significantly lower accuracy（t=-4.38,P〈0.05）and longer reaction time（t=4.66,P〈0.05）of RVP;Significantly less corret hits（t=-6.31^-3.62, P〈0.05）and longer reaction time（t=3.45~4.17,P〈0.05）in many different forms of DMS;Significantly more to-tal errors（t=3.33,P〈0.05）,more extradimensional errors（t=2.48,P〈0.05）and more finished numbers （t=2.59,P〈0.05）of IED.For patients with the first-episode generalized anxiety disorder,GAD-7,SAI and TAI had significantly positive correlation with mean reaction time of many different forms of DMS and extradimensional er-rors of IED（P〈0.05）,GAD-7 and SAI had significantly negative correlation with the accuracy of RVP（P〈0.05）. Conclusion：Patients with the first-episode generalized anxiety disorder have impaired cognitive function.

关 键 词：广泛性焦虑障碍 特质焦虑 状态焦虑 认知功能 

分 类 号：R395.4[哲学宗教—心理学]