首发重性抑郁症患者抗抑郁治疗前星形胶质源性蛋白(S100B)水平与短期疗效的关系  

The Relationship between Serum S100B Level and Short-term Therapeutic Effect in Patients with First-episode Major Depression

作　　者：刘永红 杨坤[2] 谢光荣[3] 于雪[2] 

机构地区：[1]天津市复员退伍军人精神病疗养院,301600 [2]天津市安定医院 [3]中南大学湘雅二医院精神卫生研究所

出　　处：《中国健康心理学杂志》2016年第5期661-663,共3页China Journal of Health Psychology

基　　金：国家自然科学基金项目(30900484);天津市卫生局重点课题基金项目(编号:2010KR10)

摘　　要：目的:研究重性抑郁症患者抗抑郁治疗前S100B(星形胶质源性蛋白)水平与短期疗效的关系。方法:按照入组标准和排除标准纳入首发重性抑郁症患者36例,并对抑郁症患者在入组时通过ELISA方法检测血清S100B水平。并应用汉密尔顿抑郁量表(HAMD)评估抗抑郁治疗4周的疗效(短期疗效)。结果:1短期治疗有效的患者组入组时S100B(1.64±0.77)ng/mL,与短期治疗无效的患者组(1.04±0.31)ng/mL相比有显著差异性(t=-3.276,P<0.05);2重性抑郁症患者血清S100B与ΔHAMD变化值成正比(r=0.389,P<0.05)。结论:首发重性抑郁症患者抗抑郁治疗前的S100B水平能够预测不同的短期疗效。Objective：To investigate the relationship between serum S100B and short-term therapeutic effect in patients with first-episode major depressive disorder（MDD）.Methods：36 patients with first-episode major depres-sion were recruited in the study.Serum S100B levels were measured in 36 MDD patients by ELISA,and therapeutic effect（4 weeks short-term effect）were evaluated by HAMD.Results：①There were significant differences in serum S100B level between effective patients group and no effective patients group（t=-3.276,P〈0.05）.②Serum S100B levels were correlated with the change of HAMD（ΔHAMD）in major depression（r=0.389,P〈0.05）.Conclusion：S100B before antidepressant treatment can predict therapeutic effect in patients with first-episode major depression.

关 键 词：抑郁症 星形胶质源性蛋白 短期疗效 汉密尔顿抑郁量表 

分 类 号：R395.4[哲学宗教—心理学]