保守手术联合不同药物对子宫内膜异位症疼痛缓解的临床分析  

Clinical analysis of the pain relief of drug therapy after conservative surgery for endometriosis

作　　者：寇明捷[1] 王佃卫[1] 李宁[1] 杨宝霞[1] 李静[1] 

机构地区：[1]山东省滨州市中心医院,山东滨州251700

出　　处：《吉林医学》2016年第5期1090-1091,共2页Jilin Medical Journal

摘　　要：目的:保守手术联合各类药物在子宫内膜异位症治疗中缓解疼痛的临床效果。方法:收集子宫内膜异位症保守术术后联合药物治疗方面的随机对照试验,以孕三烯酮为代表药物对照其他常用治疗子宫内膜异位症的药物在疼痛缓解方面的数据进行分析。结果:子宫内膜异位症保守手术术后应用孕三烯酮与单纯保守手术组比较在疼痛缓解情况优于单纯手术组(P<0.000 01),保守手术术后应用孕三烯酮与保守手术术后应用GnRH-a比较在疼痛缓解情况不如GnRH-a(P<0.000 01),保守术后应用孕三烯酮、妈富隆、米非司酮、达那唑在在疼痛缓解率方面疗效相当。结论:子宫内膜异位症保守手术术后应用药物治疗较单纯手术可明显改善疼痛症状;保守术后应用GnRH-a在疼痛缓解率方面优于孕三烯酮;保守术后应用孕三烯酮、妈富隆、米非司酮、达那唑在疼痛缓解率方面疗效相当。Objective Clinical application value of the conservative surgery with various types of drugs in the treatment of endometriosis. Method To collect relevant randomized controlled trials of the conservative surgery with drugs in the treatment of endometriosis. To take gestrinone as the representative drug compared with other commonly used drugs in the treatment of endometriosis,and the data in the aspect of pain relief. Results Compared endometriosis after conservative surgery using gestrinone group with conservative surgery alone group,pain relief was better than surgery alone group（ P〈0. 000 01）,Compared endometriosis after conservative surgery using gestrinone group with endometriosis after conservative surgery using GnRH- a group pain relief was not as good as GnRH- a（ P〈0. 000 01）,There was similar efficacy in pain relief rate after conservative surgery using gestrinone,Marvelon,mifepristone,and danazol. Conclusion Endometriosis after conservative surgery using drug therapy can significantly relieve pain rate. Endometriosis after conservative surgery using GnRH- a is superior to gestrinone in relieving pain rate. There is similar efficacy in pain relief rate after conservative surgery using gestrinone,Marvelon,mifepristone,and danazol.

关 键 词：子宫内膜异位症 药物治疗 孕三烯酮 GNRH-A 米非司酮 达那唑 妈富隆 

分 类 号：R711.71[医药卫生—妇产科学]