肾动脉去交感神经术治疗心力衰竭——希望还是炒作  

Renal Sympathetic Denervation for Heart Failure——Hopes or Hypes

作　　者：罗秀林 张烁[1,2] 

机构地区：[1]哈尔滨医科大学研究生院,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第二医院心内科,黑龙江哈尔滨150086

出　　处：《心血管病学进展》2016年第3期268-271,共4页Advances in Cardiovascular Diseases

摘　　要：心力衰竭是几乎所有心脏疾病的最终转归,每年至少有100万人因此而住院,是重大的公共卫生问题。尽管药物和一些非药物的治疗改善了心力衰竭患者的症状和病死率,但仍有很大的局限性。交感神经系统长久以来就是心力衰竭的一个潜在治疗靶点,在过去的5年间,肾动脉去交感神经术已经成为一种新型的降低交感神经兴奋性的途径,许多动物实验及临床实验证明其可以改善心力衰竭症状。近来,REACH-Pilot实验初步证明了肾动脉去交感神经术用于治疗心力衰竭是可行的、潜在有效的、安全的。Heart Failure（ HF）,is the final outcome for almost all kinds of heart diseases,which accounts for millions of people hospitalized annually,making it a highly important public health issue. Although pharmacological therapy and some non-drug treatments have been approved to improve the symptoms and survival rates in HF patients,many limitations remain. The sympathetic nervous system has long been recognized as a potential target for therapy in HF. In the past 5 years,renal sympathetic denervation has emerged as a novel approach to decrease sympathetic activity,and has been shown to significantly improve HF outcomes in both HF animal models and patients^（[1]）. And the REACH-Pilot study has provided the initial clinical evidence that renal sympathetic denervation was feasible,potential effective,and safe in patients with HF^（[2]）.

关 键 词：心力衰竭 肾动脉去交感神经术 交感神经系统 

分 类 号：R541.6[医药卫生—心血管疾病]