S100A1蛋白基因治疗心力衰竭的研究进展  

Research Progress in S100A1 Gene Therapy for Heart Failure

作　　者：陈焕[1,2] 邓平[2] 

机构地区：[1]南华大学,湖南衡阳421001 [2]长沙市中心医院心内科,湖南长沙410004

出　　处：《心血管病学进展》2016年第3期302-305,共4页Advances in Cardiovascular Diseases

摘　　要：心力衰竭是各种心脏疾病发展的终末阶段。S100A1蛋白高度特异性表达于心肌细胞,在心力衰竭时,其表达明显降低。S100A1蛋白可具有抑制心肌程序性细胞死亡、逆转心肌重构、改善心肌细胞能量供应及增强心肌细胞收缩力的作用。近年来,许多研究发现S100A1蛋白高表达可用于治疗心力衰竭。Heart failure is the common endpoint of various cardiovascular diseases. S100A1 is abundantly present in normal human myocardial tissue,and its expression levels are diminished in failing myocardium. S100A1 protein can induce cardiomyocyte apoptosis,reverse myocardial remodeling,improve energy homeostasis and increase both systolic and diastolic cardiac function. In recent years,many studies have found that S100A1 over-expression in cardiomyocytes can be used in the treatment of heart failure.

关 键 词：S100A1蛋白 心力衰竭 基因治疗 

分 类 号：R541.6[医药卫生—心血管疾病] R450[医药卫生—内科学]