心脏干细胞修复梗死心肌作用机制的研究进展  

Research Progress of Cardiac Stem Cells Repairing Infarction Myocardial Function Mechanism

作　　者：王艳[1] 石蓓[1,2] 

机构地区：[1]遵义医学院研究生院,贵州遵义563003 [2]遵义医学院附属医院心内科,贵州遵义563003

出　　处：《心血管病学进展》2016年第3期315-318,共4页Advances in Cardiovascular Diseases

摘　　要：心脏干细胞被发现于哺乳动物心脏组织中已有十余年,在此期间的众多研究均证实了心脏干细胞可再生修复梗死心肌,改善心脏功能。研究者们认为心脏干细胞发挥修复梗死心肌的作用机制可能与其固有特性相关,包括直接分化为功能心肌细胞,通过旁分泌各种细胞因子改善心肌梗死区域微环境,促进血管新生。现对心脏干细胞作用机制的研究现状及所面临的问题进行综述,以期为转化医学发展与心脏疾病的防治开拓新的方向与策略。Cardiac stem cells（ CSCs） were found in the tissue of the mammalian heart has more than 10 years. During this time many of the studies have confirmed that CSCs can regenerate and repair infarcted myocardium and improve heart function. The researchers argue that CSCs play to the role of the repair infarcted myocardium mechanism may be related to its inherent characteristics including direct differentiation into functional myocardial cells. Through paracrine microenvironment of various cytokines,myocardial infarction area will be improved and angiogenesis promoted. In this paper,the current research mechanisms of CSCs that repair infarcted and the problems facing were reviewed in order to find a new direction and strategy for the development of transforming medicine and heart disease prevention.

关 键 词：心脏干细胞 外泌体 心肌梗死 再生治疗 

分 类 号：R542.22[医药卫生—心血管疾病]