初诊2型糖尿病患者血清铁蛋白与动脉粥样硬化的相关性研究  

Correlation between Serum Ferritin and Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetes Mellitus

作　　者：周志龙[1] 

机构地区：[1]江苏连云港市中医院,江苏连云港222061

出　　处：《赣南医学院学报》2016年第2期232-234,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:旨在调查初诊2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清铁蛋白(serum ferritin,SF)水平与动脉粥样硬化的关系。方法:依据颈动脉内膜中层厚度(carotid intima-media thickness,CIMT),将64例初诊T2DM患者分为非颈动脉粥样硬化(non-carotid atherosclerosis,NCAS)组和颈动脉粥样硬化(carotid atherosclerosis,CAS)组。比较两组患者SF以及代谢参数方面的差异。结果:CAS组餐后2 h血糖(postprandial blood glucose,PPG)、糖化血红蛋白(Hemoglobin A1c,Hb A1c)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDLC)、C反应蛋白(C reative protein,CRP)、稳态模型评估胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)和SF水平均显著高于NCAS组,Pearson相关分析示SF与PPG、Hb A1c、LDL-C、CRP、HOMAIR和CIMT呈正相关。结论:SF水平升高与初诊T2DM患者动脉粥样硬化密切相关。Objective： To investigate the correlation between serum ferritin and atherosclerosis in newly diagnosed type 2diabetes mellitus. Methods： According to carotid intima media thickness,84 patients with newly diagnosed type 2 diabetes mellitus were divided into non-carotid atherosclerosis group and carotid atherosclerosis group. Serum ferritin and clinical characteristics of the two groups were compared. Results： Compare with NCAS group,the level of PPG,Hb A1 c,LDL-C,CRP,HOMA-IR and ferritin were significant higher in CAS group. In Pearson correlation analysis,serum ferritin were positively associated with PPG,Hb A1 c,LDL-C,CRP,HOMA-IR and carotid intima media thickness. Conclusion： Higher serum ferritin was strongly associated with the development of atherosclerosis in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 动脉粥样硬化 铁蛋白 

分 类 号：R587.1[医药卫生—内分泌]