血清尿酸和同型半胱氨酸关系的研究  

Research of relationship between uric acid and homocysteine in serum

作　　者：刘艺[1] 张健[1] 

机构地区：[1]无锡市儿童医院医学检验科,江苏无锡214023

出　　处：《国际检验医学杂志》2016年第10期1348-1349,共2页International Journal of Laboratory Medicine

摘　　要：目的研究血清尿酸(UA)和同型半胱氨酸(HCY)的关系。方法选取504例受检者,分为高HCY组和正常HCY组,计算体质量指数(BMI)及血清HCY、UA、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、维生素B12(VitB12)、叶酸水平。结果血清高HCY组UA水平[(368.8±83.3)μmol/L]高于正常HCY组[(321.2±83.3)μmol/L],差异具有统计学意义(P<0.05)。血清UA水平与HCY水平呈正相关(r=0.14,P<0.05)。Logistic回归分析预测血清高HCY、UA、VitB12及叶酸进入回归方程,UA的危险度(OR)为1.72。结论血清UA和HCY存在相关关系,血清高UA患者患高HCY血症风险高于UA正常者。Objective To evaluate the relationship between homocysteine（HCY）and uric acid（UA）in serum.Methods 504 subjects were chose to assess body mass index（BMI）and level of HCY,UA,high density lipoprotein,low density lipoprotein,Vitamin B12（VitB12）and folic acid in serum.Results Serum levels of UA [（368.8±83.3）μmol/L]in subjects with high HCY serum level were higher than those[（321.2±83.3）μmol/L]with normal HCY serum level（P〈0.05）.A positive association was found between HCY serum levels and UA serum levels（r=0.14,P〈0.05）.Logistic analysis revealed that UAOR=1.72.ConclusionThere is relationship of serum UA and HCY,and the hyper homocysteine risk of patients with higher serum UA are higher than the patients with normal level of UA.

关 键 词：同型半胱氨酸 尿酸 动脉粥样硬化 高HCY血症 

分 类 号：R589[医药卫生—内分泌] R446.11[医药卫生—内科学]