加味大柴胡汤治疗原发性肝癌患者TACE术后综合征的临床观察  

Clinical Observation of Modified Dachaihu Decoction(加味大柴胡汤) in the Treatment of Postoperative Syndrome of Primary Liver Cancer Patients with Transcatheter Hepatic Arterial Chemoembolization

作　　者：乔喜婷 王克穷[2] 闫明亮 乔秋飞[2] 张兆国[3] 于明洋[2] 王会仓[2] 岳黎明[2] 

机构地区：[1]咸阳市中心医院,陕西咸阳712000 [2]陕西中医药大学附属医院,陕西咸阳712046 [3]陕西中医药大学,陕西咸阳712046

出　　处：《中医药导报》2016年第11期28-31,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：咸阳市科技计划项目(2012k16-01)

摘　　要：目的:观察加味大柴胡汤治疗原发性肝癌患者经导管肝动脉化疗栓塞术(TACE)术后综合征的临床疗效,为中医药防治原发性肝癌提供临床证据。方法:纳入接受TACE术治疗的中晚期原发性肝癌患者80例,随机分为两组,对照组采用TACE术后常规西药对症支持治疗;治疗组在常规西药对症治疗的基础上加服加味大柴胡汤,治疗2周。观察治疗前后两组患者的中医证候积分和TACE术后综合征的持续时间和程度;在治疗前、治疗1周和治疗2周后分别进行KPS评分和血清AFP检测。结果:治疗组总有效率为79.5%,对照组总有效率为62.2%,治疗组临床中医证候疗效明显优于对照组(P<0.05);治疗组TACE术后发热、恶心呕吐、便秘、肝区疼痛的持续时间与对照组比较,差异均有统计学意义(P<0.05);与TACE术前比较,两组患者TACE术后1周和2周KPS评分均增加,血清AFP均下降,差异均有统计学意义(P<0.05);与对照组比较,治疗组TACE术后1周和2周KPS评分明显升高,TACE术后2周血清AFP降低,差异均有统计学意义(P<0.05)。结论:加味大柴胡汤可明显降低TACE术后中医证候积分和发热、恶心呕吐、便秘、肝区疼痛等TACE术后综合征症状程度和持续时间,降低血清AFP含量,提高KPS评分,改善患者生活质量。Objective： To observe the clinical efficacy of modified Dachaihu decoction on postoperative syn- drome of primary liver cancer patients with Transcatheter hepatic arterial chemoembolization, to provide clinical evidence for TCM prevention and treatment of primary liver cancer. Methods： The 80 patients of Transcatheter hepatic arterial chemoembolization middle-late with primary liver cancer were randomly divided into two groups; Patients were given conventional TACE postoperative routine western medicine support therapy in control group, and modified Dachaihu decoction as well as routine western medicine therapy in treatment group, for 2 weeks. The TCM syndrome integral and the duration and degree of postoperative syndrome with TACE were observed in two groups, before and after the treatment. KPS score and serum AFP were tested before treatment, 1st and 2nd week after treatment. Results： The total effective rate was 79.5% in treatment group, and 62.2% in control group, and the treatment group showed better clinical syndrome curative effect than control group （P〈0.05）. Treatment group of The comparison on nausea and vomiting, constipation, liver area pain degree and the duration between the treatment and control groups showed significant differences （P〈0.05）. The KPS scores were increased and serum AFP decreased in two groups, postoperative 1 week and 2 weeks, and the difference was statistically significant （P〈0.05）; Comparing with the control group, the KPS score increased, postoperative 1 week and 2 weeks and serum AFP decreased significantly postoperative 2 weeks, in treatment group, with sta- tistically significant difference was （P〈0.05）. Conclusion： The modified Dachaihu decoction can obviously reduce postoperative syndromes with TACE, nausea and vomiting, constipation, liver area for TACE postoperative syndrome symptoms degree and duration, reduce the content of serum AFP, improve KPS score, and improve the quality of life.

关 键 词：原发性肝癌 加味大柴胡汤 经导管肝动脉化疗栓塞术 TACE术后综合征 

分 类 号：R273[医药卫生—中西医结合]