The role of galectin-4 in physiology and diseases  

作　　者：Zhan-Qi Cao Xiu-Li Guo 

机构地区：[1]Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 50012, China

出　　处：《Protein & Cell》2016年第5期314-324,共11页蛋白质与细胞（英文版）

摘　　要：Galectin-4, a tandem repeat member of the β-galactoside-binding proteins, possesses two carbohydraterecognition domains （CRD） in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.Galectin-4, a tandem repeat member of the β-galactoside-binding proteins, possesses two carbohydraterecognition domains （CRD） in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.

关 键 词：galectin-4 lipid raft CROSSLINKER intestinalinflammation tumor progression 

分 类 号：Q946.1[生物学—植物学] S511.01[农业科学—作物学]