雷公藤多苷联合甲氨蝶呤治疗类风湿关节炎的临床疗效研究  

Clinical efficacy of tripterygium glycosides combined with methotrexate in the treatment of rheumatoid arthritis

作　　者：毕丹艳[1] 李芹[1] 张虹[1] 郑红梅[1] 王静[1] 毕丹青[2] 彭江云[3] 

机构地区：[1]云南省第一人民医院风湿免疫科,昆明650031 [2]昆明医科大学第一附属医院肾内科,昆明650032 [3]云南中医学院第一附属医院风湿科,昆明650021

出　　处：《中国临床药理学杂志》2016年第10期880-882,共3页The Chinese Journal of Clinical Pharmacology

基　　金：云南省重点新产品开发计划基金资助项目(2012BC010)

摘　　要：目的观察雷公藤多苷联合甲氨蝶呤在类风湿关节炎患者中的临床疗效。方法 80例类风湿关节炎患者随机分为2组,每组40例。对照组每次口服甲氨蝶呤10 mg,每周1次,试验组在对照组基础上口服雷公藤多苷20 mg,每天3次,2组均连续治疗12周,比较2组患者的临床疗效。结果治疗后,试验组晨僵时间、关节疼痛数、关节压痛数、疼痛评分显著低于对照组(P<0.05)。试验组治疗后红细胞沉降率(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)显著低于对照组(P<0.05)。结论雷公藤多苷联合甲氨蝶呤在类风湿关节炎患者中有较好的临床疗效。Objective To investigate the clinical effect of tripterygium glycosides combined with methotrexate in the treatment of patients with rheumatoid arthritis.Methods Eighty patients were randomly divided into treatment group and control group,40 cases each.Patients in control group were orally given methotrexate 10 mg,1 times a week.Patients in treatment group were orally given tripterygium glycosides 20 mg,three times a day on the basis of control group.All patients were treated for 12 weeks.The clinical efficacy was compared between the two groups.Results After treatment,the morning stiffness,joint pain count,tender joint count,pain score in treatment group were significantly lower than those in control group（ P〈0.05）.The erythrocyte sedimentation（ ESR）,C-reactive protein（ CRP）,rheumatoid factor（ RF） in treatment group after treatment were significantly lower than those in control group（ P〈0.05）.Conclusion Tripterygium glycosides combined with methotrexate in the treatment of rheumatoid arthritis had a good clinical effect.

关 键 词：雷公藤多苷 甲氨蝶呤 类风湿关节炎 药代动力学 

分 类 号：R971.1[医药卫生—药品]