肺表面活性物质治疗早产儿呼吸窘迫综合征给药时间的研究概况  

Research progress on the time of administration of pulmonary surfactant for the treatment of respiratory distress syndrome in premature infants

作　　者：黄宏坤[1] 廖克准 韦海林 谭毅[1] 

机构地区：[1]河池市第三人民医院儿科,广西547000 [2]河池市妇幼保健院儿科,广西547000

出　　处：《中国临床新医学》2016年第5期458-461,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：肺表面活性物质(pulmonary surfactant,PS)已常规用于新生儿呼吸窘迫综合征的防治,其疗效肯定,并有大量文献报道其使用效果、给药方式、使用剂量等临床研究。但关于PS最佳给药时间的研究不多,给药时间与给药目的紧密相关,主要有早期的预防性给药、中期的替代治疗抢救性给药、晚期的挽救性给药和重复给药,因我国医疗发展的客观条件、治疗理念差别等因素在使用PS的时间界点上各有报道,该文对PS治疗早产儿呼吸窘迫综合征给药时间的研究情况作一概述。Pulmonary surfactant（ PS） has been conventionally used for prevention and treatment of neonatal respiratory distress syndrome（ NRDS）. A large number of literature on the clinical effects,the mode of administration,and the dosage of PS for the treatment of NRDS have been reported,but there are few researches on the optimal time of administration at present. The time of administration is closely related to the purposes of administration,including a prophylactic administration in the early stage,an alternative therapy for salvaging administration in the middle stage and a rescuing and repeated administration in the late stage of NRDS. Due to the different medical conditions and concepts of using PS,different time intervals of administration of PS have been reported in different parts of China. How to effectively administer PS in different patients in different levels hospitals needs to be further investigated.In this paper,the time of administration of PS for the treatment of respiratory distress syndrome in premature infants is reviewed.

关 键 词：肺表面活性物质 呼吸窘迫综合征 给药时间 研究概况 

分 类 号：R722.6[医药卫生—儿科]