血管紧张素Ⅱ-2型受体在心血管疾病炎症反应中的作用  

Effects of angiotensin Ⅱ type-2 receptor on inflammatory reactions in cardiovascular diseases

作　　者：杜明君[1] 连锋[1] 薛松[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心血管外科,上海200127

出　　处：《上海交通大学学报（医学版）》2016年第5期772-775,786,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委医学引导项目(124119a2100)~~

摘　　要：心血管疾病多伴有慢性炎症反应。肾素—血管紧张素系统(RAS)参与心血管炎症的发生和发展,血管紧张素Ⅱ(ANGⅡ)的炎症作用主要通过其1型受体(AT_1受体)实现。相较于AT_1受体,人们对ANGⅡ2型受体(AT_2受体)的了解还不是很深入。近年来发现AT_2受体也参与许多心血管疾病炎症反应进程,激活AT_2受体能从不同层面抑制炎症的发展。该文就AT_2受体参与调节心血管系统炎症反应的机制作一综述。Most cardiovascular diseases are associated with chronic inflammatory reactions. The rennin angiotensin system（ RAS） is involved in occurrence and development of the cardiovascular inflam m ation. The inflam matory effect of angiotensin Ⅱ（ Ang II） is m ainly achieved via the Ang Ⅱ type-1（ AT1） receptor.However, Ang Ⅱ type-2（ AT2） receptor is less well understood as com pared with AT1 receptor. Recent studies have found that AT2 receptor also participates in the inflam matory reaction process of m any cardiovascular diseases. Stim ulated AT2 receptor can inhibit the developm ent of inflam m ation at different levels. This paper reviews mechanism of the involvem ent of AT2 receptor in regulating inflam m atory reactions of cardiovascular system.

关 键 词：血管紧张素Ⅱ AT2受体 炎症 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]