抗栓Ⅰ号对不稳定性心绞痛的血液流变学及Hs-CRP的影响  

Effect of Kangshuan TypeⅠon Hemorrheology and Hs-CRP of Patients with Unstable Angina Pectoris

作　　者：刘晴晴[1] 姜昆[1] 陈晓虎[2] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]江苏省中医院,江苏南京210029

出　　处：《辽宁中医杂志》2016年第5期997-999,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81273943)

摘　　要：目的:观察抗栓Ⅰ号对冠心病不稳定性心绞痛(心血瘀阻型)患者的临床疗效、血液流变学及超敏C反应蛋白的影响。方法:本院78例不稳定性心绞痛(心血瘀阻型)患者随机分为两组,治疗组(以常规治疗方法加用抗栓Ⅰ号,不用阿司匹林)45例,对照组(用常规治疗方法,加用阿司匹林)33例,治疗时间为4周,观察两组临床症状、血液流变学及超敏C反应蛋白的变化,并与治疗前对比。结果:临床有效率抗栓Ⅰ号组为88.9%,阿司匹林组75.8%(P<0.05);中医证候积分两组治疗后均明显降低(P<0.05),但组间比较差异无统计学意义(P>0.05);两组治疗后全血高切黏度、低切黏度、血浆黏度、D-二聚体及红细胞沉降率与治疗前比较有统计学意义(P<0.05);血清超敏C反应蛋白水平两组存在差异,与治疗前比均有统计学意义(P<0.05)。结论:抗栓Ⅰ号可改善不稳定性心绞痛(心血瘀阻型)患者的临床症状,血液流变学并降低其炎症反应。Objective： To observe the effect of Kangshuan TypeⅠon symptoms,hemorrheology and hypersensitive C- reactive protein（ Hs- CRP） of patients with unstable angina pectoris（ stagnation of the heart blood）. Methods： Totally seventy- eight UAP cases were randomly divided into 2 groups： the treatment group（ conventional therapy with Kangshuan TypeⅠ,45 cases）and the control group（ routine postoperative therapy with Aspirin,33 cases）. The treatment time was 4 weeks. The clinical efficacy and changes in hemorrheology and Hs- CRP were observed. Results： The symptoms were relieved. After the treatment,the two groups showed statistics significance in effective rate（ effective rate of the treatment group 88. 9%; effective rate of the control group 75. 8%）,TCM syndrome scoring,the whole blood high shear viscosity,low shear viscosity,plasma viscosity,D- dimer,erythrocyte sedimentation rate（ ESR） and Hs- CRP when compared with values before the treatment（ P 0. 05） and the treatment group＇s were more obvious with statistics significance（ P 0. 05）. Conclusion： Kangshuan TypeⅠcan improve clinical symptoms,hemorrheology and reduce the inflammatory responses in patients with unstable angina pectoris（ stagnation of the heart blood）.

关 键 词：抗栓Ⅰ号 不稳定性心绞痛 血液流变学 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]