粒细胞集落刺激因子促进肝脏再生的机制  

Mechanism of granulocyte-colony stimulating factor accelerating liver regeneration

作　　者：许祥[1] 胡瑾华[1] 

机构地区：[1]北京大学解放军第三二医院教学医院肝衰竭诊疗研究中心,100039

出　　处：《传染病信息》2016年第2期125-128,共4页Infectious Disease Information

基　　金：国家自然科学基金(81171641);北京市科技计划首都临床特色应用研究项目(Z131107002213157)

摘　　要：肝脏的一个特性即是在受到损伤后会通过自身的再生能力来恢复原有肝脏体积和功能,目前越来越多的证据显示重组人粒细胞集落刺激因子(granulocyte-colony stimulating factor,G-CSF)在促进肝脏再生的过程中有多方面的作用。深入了解G-CSF促进肝脏再生的机制对于其应用于肝损伤患者,促进肝脏再生,提高生存率有着重要意义。本文就G-CSF促进肝脏再生的机制进行综述。The liver is unique in its ability to regenerate itself and thereby restore its original mass and function after injury. Nowadays, increasing evidence suggests that the granulocyte-colony stimulating factor（G-CSF） plays important roles in accelerating the liver regeneration process. The deep understanding of the effect of G-CSF on liver regeneration has important significance in the use of G-CSF for the treatment of patients with liver injury to accelerate the liver regeneration and improve survival. This review focuses on the mechanism of G-CSF in accelerating liver regeneration.

关 键 词：粒细胞集落刺激因子 肝再生 干细胞 

分 类 号：R392.114[医药卫生—免疫学]