北京市昌平区成年人TG/HDL-C水平与糖尿病和糖尿病前期患病关系的研究  

Relationship between triglyceride to high density lipoprotein cholesterol ratio and prevalence of diabetes and prediabetes in adults in Changping district,Beijing

作　　者：孟德敬[1] 耿坤[1] 王秀云[1] 白云[1] 徐志鑫[1] 张倩[1] 

机构地区：[1]北京市昌平区疾病预防控制中心,北京102200

出　　处：《疾病监测》2016年第4期329-333,共5页Disease Surveillance

摘　　要：目的分析北京市昌平区成年人甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）水平与糖尿病和糖尿病前期患病的关系。方法研究对象为参加2013年北京市昌平区卫生与人群健康状况调查的18~79岁昌平区常住居民。研究对象个人信息通过问卷调查获得。根据TG/HDL-C在人群中分布情况,对男性及女性TG/HDL-C分别按照四分位数法分组。研究结局包括糖尿病、糖尿病前期以及糖尿病和糖尿病前期。结果调查对象3895人,其中男性1745人,女性2150人。调查结果显示,糖尿病患者、糖尿病前期人群、糖尿病和糖尿病前期患者分别为413、1016和1429人。经多因素logistic模型分析,在男性人群中,与〈0.66组相比,1.08~1.74组和≥1.75组糖尿病患病风险OR值（95%CI）分别为2.23（1.35~3.68）和2.36（1.43~3.91）;糖尿病和糖尿病前期患病风险OR值（95%CI）分别为1.38（1.01~1.87）和1.80（1.32~2.45）;≥1.75组糖尿病前期患病风险OR值（95%CI）为1.58（1.13~2.21）。在女性人群中,与〈0.57组相比,0.83~1.30组和≥1.31组糖尿病患病风险OR值（95%CI）分别为2.65（1.56~4.49）和3.72（2.23~6.22）;糖尿病前期患病风险OR值（95%CI）分别为1.60（1.16~2.20）和2.20（1.59~3.04）;糖尿病和糖尿病前期病患病风险OR值（95%CI）分别为1.78（1.32~2.39）和2.55（1.88~3.44）。结论随着TG/HDL-C水平的增加,糖尿病患病风险以及糖尿病前期患病风险均逐渐升高。Objective To examine the association between triglyceride to high density lipoprotein cholesterol（ TG / HDL-C）ratio and prevalence of diabetes and prediabetes in adults in Changping district,Beijing. Methods Data were collected from Changping Health and Population Health Status Survey in 2013 with a standard questionnaire. Participants aged 18- 79 years were divided into four groups according to quartiles of TG / HDL-C ratio in men and women,respectively. The outcome included diabetes,prediabetes and diabetes / prediabetes. Results A total of 3895 participants（ 1745 men and 2150 women）were eligible for final data analysis. A total of 413 adults with diabetes,1016 adults with prediabetes,and 1429 adults with diabetes / prediabetes were recorded in the investigation. Multivariate logistic regression analysis indicated that the odds ratio（ OR） of diabetes was 2. 23（ 95% CI： 1. 35- 3. 68） and 2. 36（ 95% CI： 1. 43- 3. 91）,respectively,and the OR of diabetes/prediabetes was 1. 38（ 95% CI： 1. 01- 1. 87） and 1. 80（ 195% CI： 1. 32- 2. 45）,respectively,in men with TG / HDL-C ratio of 0. 83- 1. 30 and ≥ 1. 31,and the OR of prediabetes was 1. 58（ 95% CI： 1. 13- 2. 21） in men with TG / HDL-C ratio ≥1. 75 compared with men with TG / HDL-C ratio 〈0. 66. In women,the OR of diabetes in those with TG / HDL-C ratio of0. 83- 1. 30 and ≥ 1. 31 was 2. 65（ 95% CI： 1. 56- 4. 49） and 3. 72（ 95% CI： 2. 23- 6. 22） respectively,the OR of prediabetes was 1. 60（ 95% CI： 1. 16- 2. 20） and 2. 20（ 95% CI： 1. 59- 3. 04） respectively,and the OR of diabetes /prediabetes was 1. 78（ 95% CI： 1. 32- 2. 39） and 2. 55（ 95% CI： 1. 88- 3. 44） respectively compared with those with TG /HDL-C ratio 〈0. 57. Conclusion Increased TG / HDL-C ratio was significantly associated with increased risk of prevalence of both diabetes and prediabetes.

关 键 词：甘油三酯 高密度脂蛋白胆固醇 糖尿病 糖尿病前期 

分 类 号：R587.1[医药卫生—内分泌]