HIV/AIDS病人抗病毒治疗6个月后住院原因分析  

Analysis on hospitalization causes of HIV/AIDS patients after six-month's HAART

作　　者：吴念宁[1] 彭智鹏[1] 黄绍标[1] 

机构地区：[1]南宁市第四人民医院广西艾滋病临床治疗中心,南宁530023

出　　处：《中国艾滋病性病》2016年第5期312-314,共3页Chinese Journal of Aids & STD

基　　金：国家重大科技专项项目课题(2012ZX10004910-006);南宁市科学研究与技术开发计划项目(201109047C)~~

摘　　要：目的了解广西地区艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)经高效联合抗反转录病毒治疗(HAART)超过6个月后,所患疾病谱及对预后的影响。方法回顾性分析2010年4月至2015年3月HAART超过6个月后,HIV/AIDS病人住院的主要原因。将所患疾病分类为:HAART药物不良反应、急性感染性疾病、传染性肝病、结核病、其他传染病、内科系统疾病、外科系统疾病、外伤、肿瘤、其他疾病,共10类。观察各类疾病的发生情况及对预后的影响。结果共收集符合条件的病人818例,男性占71.1%,年龄>50岁的占47.1%,CD4+T淋巴细胞计数<200个/μL者占32.5%。各类疾病中,急性感染性疾病占19.6%,内科系统性疾病占17.0%,外科系统性疾病占13.8%,肿瘤占12.6%,HAART药物不良反应占8.3%,结核病占8.9%,传染性肝病占5.7%,其他传染病占5.0%,外伤占3.7%,其他疾病占5.4%。不良预后病人占10.9%。其中前三位为恶性肿瘤(47.2%)、急性感染(25.8%)和慢性肝病(9.0%)。结论广西地区HIV/AIDS病人基础免疫低下多见,中长期HAART过程中感染性疾病风险较大,老年人比例高,合并病种多样,恶性肿瘤和感染是不良预后的主要原因。Objective To investigate the disease spectrum and influence on prognosis of HIV/AIDS patients under highly active antiretroviral therapy（HAART）over six months in Guangxi.Methods A retrospective analysis was made for the hospitalization causes of HIV/AIDS patients under HAART over six months during April 2010 to March 2015.The incidence of the diseases was observed and analyzed including side effects of HAART,acute infectious diseases,infectious hepatitis,tuberculosis,other infectious diseases,internal system diseases,surgical system diseases,trauma,cancers and miscellaneous,and the influence on the prognosis.Results A total of 818 conditioned cases were collected with 71.1% of males,47.1% over the age of 50 years,and 32.5% whose CD 4＋T-lymphocyte count below 200copies/μL.Among the various diseases described above,acute infectious diseases accounted for 19.6%,internal systemic diseases for 17%,surgical system diseases for 13.8%,cancers for 12.6%,HAART side effects for 8.3%,tuberculosis for 8.9%,infectious hepatitis for 5.7%,other infectious diseases for5%,trauma for 3.7%,and other diseases for 5.4%.Patients of poor prognosis accounted for 10.9%.Among them the top three were cancers（47.2%）,acute infections（25.8%）,and chronic liver diseases（9%）.Conclusion HIV/AIDS patients in Guangxi are mostly immunocompromised.The risks of opportunistic infections are still high in the medium and long term process of HAART.A high proportion has been seen in aged patients with diversity of complications and diseases.The main causes of poor prognosis remain cancers and infections.

关 键 词：艾滋病病毒感染者/艾滋病病人 高效联合抗反转录病毒治疗 住院原因 疾病谱 

分 类 号：R373.9[医药卫生—病原生物学] R512.91[医药卫生—基础医学]