脑心通胶囊和氯吡格雷联合治疗糖尿病合并脑梗塞58例  

Naoxintong Capsule and Clopidogrel Treatment of Diabetes Complicated with Cerebral Infarction in 58 Cases

作　　者：张建勋 

机构地区：[1]济宁市任城区安居街道卫生院,山东济宁272059

出　　处：《糖尿病新世界》2016年第6期16-17,20,共3页Diabetes New World Magazine

摘　　要：目的观察脑心通胶囊和氯吡格雷联合治疗糖尿病合并脑梗塞的临床效果。方法将2013年6月—2015年6月住院的糖尿病性脑梗死患者116例,随机分为对照组和观察组各58例,两组均给予糖尿病饮食,应用降糖药物控制血糖,保护神经细胞、抗凝、降脂等常规治疗手段,对照组给予口服氯吡格雷,75 mg 1次顿服;观察组在口服氯吡格雷的同时,加服脑心通胶囊,1.6 g/次,3次/d口服。1个月为1个疗程。对两组糖尿病性脑梗死患者于入院时及入院1个月时,应用美国国立卫生院脑卒中量表(NIHSS)评分法进行神经功能缺损程度评估,比较患者神经功能恢复程度。结果对照组治疗前NIHSS评分为(23.1±7.8),治疗1个月后为(12.1±5.4);观察组治疗前NIHSS评分为(22.9±7.9),治疗1个月后为(7.9±2.3)。两组治疗前NIHSS评分比较,P>0.05;两组治疗后NIHSS评分与治疗前比较,P<0.05;观察组治疗后NIHSS评分与对照组比较,P<0.05。结论脑心通胶囊和氯吡格雷联合治疗糖尿病合并脑梗塞疗效可靠,神经功能缺损改善程度优于单用氯吡格雷,且服用方便,无不良反应,是治疗糖尿病合并脑梗塞的可行方法。Objective To observe the clinical effect of Naoxintong capsule and clopidogrel treatment of diabetes complicated with cerebral infarction. Methods 116 patients admitted in our hospital from June 2013 to 2015 June of diabetic patients with cerebral infarction, randomized for control group and observation group, each group of 58 cases, two groups were given diabetic diet, application of hypoglycemic drugs to control blood sugar, protect nerve cells, anticoagulation, lipid-lowering etc. of conventional treatment, control group was given oral clopidogrel, 75mg1 orally; observation of clopidogrel at the same time, plus clothing Naoxintong capsule, each 1.6 g, 3 times daily oral group. A month for 1 courses. For the two groups of diabetic patients with cerebral infarction at the time of admission and one month, the application of the United States Na-tional Institutes of Health Stroke Scale table （NIHSS） method for degree of neural function defect assessment, neurological function recovery. Results The control group before treatment NIHSS score was （23.1±7.8） months after treatment was （12.1 ±5.4）; the observation group before treatment NIHSS score was （22.9 ±7.9） months after treatment was （7.9 ±2.3）. Two groups before treatment NIHSS score comparison, P〉0.05;two group after treatment NIHSS score and before treatment com-parison, P〈0.05;observation group after treatment NIHSS score compared with the control group, P〈0.05. Conclusion Brain Naoxintong capsule and clopidogrel therapy combined with diabetes complicated with cerebral infarction and reliable, neural function defect improvement than clopidogrel alone and easy to take, no adverse reaction, is feasible for the treatment of di-abetes complicated with cerebral infarction.

关 键 词：脑心通胶囊 氯吡格雷 糖尿病 脑梗塞 

分 类 号：R977.1[医药卫生—药品]