肽类树状大分子的合成及其在药物传输系统中的应用  

Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System

作　　者：张少飞[1,2] 杨建东[2] 柳明珠[1] 吕少瑜[1] 高春梅[1] 吴灿[1] 朱召彦 

机构地区：[1]功能有机分子化学国家重点实验室兰州大学化学化工学院,兰州730000 [2]陇南师范高等专科学校,陇南742500

出　　处：《化学学报》2016年第5期401-409,共9页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.51541304;51273086);教育部高等学校博士学科点专项科研基金(No.20130211110017);陇南师范高等专科学校校级重点科研项目(No.2014LSZK01004)资助~~

摘　　要：树状大分子是近年来蓬勃发展的一类新型高分子材料,其表面存在大量的官能团,分子内部存在空腔且分子尺寸可控,因此,树状大分子已被广泛应用于众多的领域.肽类树状大分子是指在树状大分子结构中含有肽键的一类大分子,因其具有类似蛋白质一样的球状结构,且具有优异的水溶性、生物相容性、生物降解性和细胞低毒性等特点,所以,肽类树状大分子可以作为药物传输的载体.此外,肽类树状大分子的疏水空腔可以装载疏水性药物,对其起到增溶和缓释作用.综述了肽类树状大分子的合成方法,并对其与药物分子的结合机制及其在药物传输系统中的应用进行了总结与展望.Dendrimers are a novel polymer material, which have received more and more attention due to the functional groups on their surface, hydrophobic cavity and adjustable sizes. Thus, dendrimers have been widely used in many fields. Peptide dendrimer is a sort of dendritic polymer, which contains peptide bonds in the structure. Owing to the globular structure similar to the protein, excellent water solubility, biocompatibility, biodegradability and low toxicity, peptide dendrimer could be used as drug delivery carrier. In addition, hydrophobic cavity can be used to solubilize hydrophobic drugs, in which the drugs can be released slowly. The present review highlights the current status of synthesis of peptide dendrimers, and it also summarizes and forecasts the interaction mechanism between drug molecules and peptide dendrimers, and the application ofpeptide dendrimers in drug delivery system.

关 键 词：高分子材料 肽类树状大分子 球状结构 药物传输 载体 

分 类 号：O631.1[理学—高分子化学]