醛固酮合酶基因-344C／T多态性与原发性高血压早期肾损害的相关性  

between aldosterone synthase gene -344C/T polymorphism and early renal damage in Han population with essential hypertension

作　　者：张琪[1] 范贵娟 张杰[1] 贠琳[1] 黄帅[1] 徐瑞[1] 李国华[1] 闫素华[1] 

机构地区：[1]山东大学附属千佛山医院心内二科,济南250014

出　　处：《中华肾脏病杂志》2016年第5期345-349,共5页Chinese Journal of Nephrology

基　　金：山东省科技发展计划项目（2014GSF118055）;山东省医药卫生科技发展计划（2013WS0130）

摘　　要：目的探讨醛固酮合酶（CYP11B2）基因-344C／T多态性在中国汉族原发性高血压患者中的分布及其与高血压早期肾损害的相关性。方法纳入418例原发性高血压患者，根据尿微量白蛋白，尿肌酐比值将患者分为高血压合并早期肾损害（RD）组（182例）和高血压不合并早期肾损害（NRD）组（236例），用Taqman探针法进行基因分型，并测定血脂、血糖、血浆醛固酮等指标进行比较。结果RD组与NRD组间CYP11B2基因-344C／T位点CC、CT、TT3种基因型及C、T等位基因频率差异均有统计学意义（均P〈0．05）；RD组TT基因型频率高于NRD组（P〈0．05），T等位基因频率高于NRD组（P〈0．05）。TT基因型血浆醛固酮水平高于CC型和CT型（P〈0．05）。在校正血压后基因型与高血压早期肾损害无相关性（P〉0．05）。结论醛固酮合酶基因-344C／T多态性与原发性高血压早期肾损害有关，T等位基因易发生高血压早期肾损害，其导致高血压早期肾损害主要依赖于血压的改变。Objective To investigate the distribution of aldosterone synthase gene -3~CFF polymorphism in patients with essential hypertension in Chinese Han population, and the association with hypertensive early renal damage. Methods Four hundred and eighteen essential hypertension cases in Shandong Provincial Qianfoshan Hospital from January 2012 to January 2015 were included in this study. According to urinary albumin/creatinine ratio, 182 cases were selected as hypertensive early renal damage group （RD group） and 236 essential hypertension without renal damage group （NRD group）. Fast venous blood was collected to detect aldosterone synthase gene -344C/T polymorphism and blood lipids, blood glucose, aldosterone and other indicators. Results There were significant differences in genotype frequency and allele frequency distribution between RD group and NRD group （P 〈 0.05）. The TT genotype and the T allele frequency in RD group were higher than those in NRD group （P 〈 0.05）. The level of aldosterone in TT genotype was higher than that in CC and CT genotype （P 〈 0.05）. The aldosterone synthase gene-344C/T polymorphism was not correlated with early renal damage in hypertension after correction of blood pressure （P 〉 0.05）. Conclusions Aldosterone synthase gene-344C/T polymorphism is associated with hypertensive early renal damage. T allele is inclined to hypertensive early renal damage. Aldosterone synthase gene -344C/T polymorphism induces renal damage through elevated blood pressure.

关 键 词：高血压 多态性 单核苷酸 醛固酮合酶 .肾损害 

分 类 号：R544.11[医药卫生—心血管疾病]