1型糖尿病骨质疏松大鼠模型的建立及评价  

Establishment and evaluation of rat type Ⅰ diabetes and osteoporosis model

作　　者：张丽媛[1] 纳青青[1] 吴天秀[1] 周满如[2] 李近[2] 刘钰瑜[2] 

机构地区：[1]广东医学院解剖学教研室,湛江524023 [2]广东医学院药理学教研室,湛江524023

出　　处：《中国骨质疏松杂志》2016年第5期532-535,共4页Chinese Journal of Osteoporosis

基　　金：2014年省公益研究与能力建设专项资金(2014A030304006)

摘　　要：目的建立I型糖尿病性骨质疏松大鼠模型,通过骨形态计量学观察该模型的改变。方法选取3月龄雄性SD大鼠60只,随机分为正常对照组(30只)和造模组(30只),造模组腹腔注射STZ60 mg/kg,诱导建立I型糖尿病性骨质疏松大鼠模型。结果从血糖、体重、骨密度、骨组织形态计量学证实该方法可以成功制备1型糖尿病性大鼠模型。结论该方法制备的I型糖尿病性骨质疏松大鼠模型,成模率高,模型稳定。Objective To establish type 1 diabetic osteoporosis rat model,and to observe the change of the model using bone histomorphometry. Methods Sixty 3-month-old male Sprague-Dawley（ SD） rats were randomly divided into normal control group（ 30 rats） and diabetic model group（ 30 rats）. Rats in the model group received intraperitoneal STZ injection（ 60 mg /kg） to establish type 1 diabetic osteoporosis rat model. Results The success of type 1 diabetic osteoporosis rat model was confirmed by determination of blood glucose,body weight,bone mineral density,and bone tissue morphology. Conclusion This method to develop type 1 diabetic osteoporosis rat model is efficient and stable.

关 键 词：1型糖尿病模型 糖尿病性骨质疏松 骨形态计量学 

分 类 号：R587.1[医药卫生—内分泌]