论脾虚及能量代谢障碍是抑郁症发病的关键病机  

Energy Metabolism Disorder and Spleen Deficiency Being the Key Pathogenesis of Depression

作　　者：丁霞[1] 靖林林[2] 文戈[3] 孙学刚[2,4] 

机构地区：[1]北京中医药大学 [2]南方医科大学中西医结合医院 [3]南方医科大学南方医院 [4]南方医科大学中医药学院

出　　处：《中医杂志》2016年第11期924-926,共3页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81230085;81173168);广东省科技厅广东省中医药科学院联合项目(2014A020221011)

摘　　要：能量代谢障碍是抑郁症病因之一,而脾虚不能升清致神失所养则是能量代谢失常诱发抑郁症的中医病机。线粒体可能是能量代谢失常致抑郁发生的超微结构基础,应激状态下内质网和线粒体的功能障碍可导致三磷酸腺苷(ATP)降低和神经元凋亡,而自噬是抑郁症发病的重要调控机制。Energy metabolism is one of the causes of depression,and mind lacking of nourishment due to spleen deficiency unable to send nutrients upward is the Chinese medicine pathogenesis of depression induced by energy metabolism disorder. Mitochondria may be the ultrastructural basis of depression induced by energy metabolism disorder.In stress state,the endoplasmic reticulum and mitochondria dysfunction may lead to a decrease in adenosine triphosphate（ ATP） and neuronal apoptosis. Autophagy is an important regulation and control mechanism of depression.

关 键 词：脾虚证 脾主升清 抑郁症 线粒体 应激 

分 类 号：R277.7[医药卫生—中医学]